OBJECTIVE To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. RESEARCH DESIGN AND METHODS We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were ...

Incidence of skeletal metastases and death from prostate cancer greatly increases with age and obesity, conditions which increase marrow adiposity. Bone marrow adipocytes are metabolically active components of bone metastatic niche that modulate the function of neighboring cells; yet the mechanisms of their involvement in tumor behavior in bone have not been explored. In this study, using exper...

OBJECTIVE Fatty acids (FAs) are the major substrate for energy production in the heart. Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium. APPROACH AND RESULTS Both FABP4/5 were abundantly expressed in capillary endothelium in the heart and skeletal muscle. The uptake of a FA anal...

BACKGROUND The early occurrence regional nodal and distant metastases cholangiocarcinoma (CCA) is one of the major reasons for its poor prognosis. However, the related mechanisms are largely elusive. Recently, increasing evidences indicate that adipocytes might be involved in the proliferation, homing, migration and invasion of several malignancies. In the present study, we attempt to determine...

PURPOSE This study aimed to determine the expression and clinical significance of proteins that are involved in lipid metabolism in human breast tumors. METHODS Tumors from 476 breast cancer patients were used to construct tissue microarrays. Then, immunohistochemistry (IHC) for hormone-sensitive lipase (HSL), Perilipin 1 (PLIN1), fatty acid binding protein 4 (FABP4), carnitine palmitoyltrans...

RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific RORα 'gain of function' mouse model under the control of the fatty acid binding protein 4 (FABP4) promoter to elucidate the function of RORα in adipose tissue. The Tg-FABP...

Degree of unsaturation of fatty acids, which is influenced by lipid source and level of metabolism in the rumen, is a major determinant in how dietary lipids affect genes that regulate beef marbling. A total of 28 Red Norte bulls with an initial live weight of 361±32 kg (P>0.05) were used in a completely randomized experimental design to analyze the expression of genes that are involved in lipi...

Skin resident memory T cells (TRM) are a subset of which reside in skin for long term. They require exogenous free fatty acid their survival, and fatty-acid binding protein 4 (FABP4) 5 (FABP5) considered to take part lipid uptake. However, the detailed relation FABP4 with TRM function is still unknown. Here, we analyzed role development functional activities murine contact hypersensitivity mode...

Abstract Background and Aims FABP4, a fatty acid-binding protein, is predominantly expressed in adipose tissue (AT) has been shown to be elevated patients with chronic kidney disease (CKD). Although levels of FABP4 have linked cardiovascular end-stage renal (ESRD) patients, the cause this increase unclear. The aim study was evaluate expression AT under uremic conditions its impact on function m...

The purpose of the present study was to identify histological biomarkers that could be used predict adipose tissue invasion by oral squamous cell carcinoma (OSCC). medical records and preoperative computed tomography scans patients with primary OSCC suspected buccal fat pad were retrospectively reviewed, an immunohistochemical candidate predictive (α-SMA, E-cadherin, N-cadherin, FABP4, Col VI, ...