Type XIX collagen is a poorly characterized member of the fibril-associated collagens with an interrupted triple helices (FACIT) class of collagen molecules. As a first step toward elucidating its function, we have isolated full size cDNA clones from the mouse alpha1(XIX) collagen gene (Col19a1) and established its pattern of expression in the developing embryo and adult organism. Col19a1 trans...

BACKGROUND There is limited information about the medium to long-term health-related quality of life (QOL) in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the determinants of medium-term QOL after the initial therapy. METHODS Following a total thyroidectomy, 88 thyroid cancer patients received either rhTSH o...

Background: Fatigue is a significant issue in rheumatoid arthritis (RA) with no accepted evidence-based management guidelines. Several studies suggested that biologic Disease Modifying Anti-Rheumatic Drugs (bDMARDs) have direct role on fatigue RA. Objectives: This study aimed to compare between patients treated bDMARDs and conventional synthetic (cs DMARDs). Methods: We conducted longitudinal i...

Background: Fatigue is a common and debilitating symptom in patients with rheumatoid arthritis (RA). RA poorly understood appears to be multifactorial. Interactions between three factors were suggested: ‘personal’, ‘disease processes’, ‘cognitive, behavioural’. Objectives: The aim of this study was determine associated fatigue persistent RA. Methods: We conducted longitudinal including (ACR/EUL...

The aim of this research is to determine the relationship between spiritual well-being levels individuals with chronic diseases and their fear COVID-19 during pandemic. study was designed conducted as cross-sectional correlational research. 323 living in Iğdır city located Eastern Anatolia Region Turkey dates 05th June 22nd 2020. Data were collected using a personal information form, Spiritual ...

INTRODUCTION Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. METHOD In this 6-month, phase 3, randomized, placebo-controlled trial, 611 patients with inadequate response to disease-modifying anti-rheumatic drugs (DMARD-IR) were randomized 4:4:1:1 to receive: tofacitinib 5 mg BID or tofacitinib 10 mg BID for the duration of the study, or placebo for 3 m...

Everyone who has reached the age of discretion is, unless the contrary is proved, presumed by law to be sane and to be accountable for his actions. This is the doctrine of mens rea. ‘Actus non facit reum nisi mens sit rea’  the deed does not make a man guilty unless his mind is guilty. This is the fundamental basis of English law. For to make a man liable to imprisonment for an offence that he...

Background Remission or low disease activity (LDA) are the common therapeutic targets in treat-to-target strategy for patients with rheumatoid arthritis (RA). Despite achieving these however, some continue to experience residual symptoms including pain, fatigue and functional loss. Patient reported outcomes (PROs) an important tool better understand lived of patient which is often not adequatel...

Background Patient-reported outcomes (PROs) such as the Patient Global Assessment (PGA) are included in definition of disease activity rheumatoid arthritis (RA). Major determinants PGA pain severity, functional limitations and fatigue. In contrast, correlation with more objective measures inflammation is weaker. early stages disease, might theory strictly reflect patient’s perception inflammati...