BACKGROUND To support the clinical distinction between systolic heart failure (SHF) and diastolic heart failure (DHF), left ventricular (LV) myocardial structure and function were compared in LV endomyocardial biopsy samples of patients with systolic and diastolic heart failure. METHODS AND RESULTS Patients hospitalized for worsening heart failure were classified as having SHF (n=22; LV eject...

It has been proposed that group III and IV muscle afferents provide inhibitory feedback from locomotor muscles to the central nervous system, setting an absolute threshold for the development of peripheral fatigue during exercise. The aim of this study was to test the validity of this theory. Thus, we asked whether the level of developed peripheral fatigue would differ when two consecutive exer...

Single solder interconnects were subjected to a series of combined tension–shear and compression–shear tests to determine their failure load. The failure envelope of these interconnects was obtained by plotting the normal component against the shear component of the failure load. The interconnect failure force map was found to be elliptical like the failure envelopes of many materials. The fail...

in this paper, numerical simulation of frp composite cylinder tubes progressive crushing processes is conducted using ls-dyna. details on the numerical modeling strategy are given and discussed. it is found that triggers introduced in the numerical simulation can effectively model the bevel trigger at the end of the tubular specimens. it is also found that two-layer finite element model based o...

the current building codes provide limited prescriptive guidance on design for protection of buildings due to progressive collapse. progressive collapse is a situation in which a localized failure in a structure, caused by an abnormal load, such as explosions or other happenings. three procedures, often employed for determination of the structural response during progressive collapse i.e. linea...

BACKGROUND In congestive heart failure (idiopathic dilated cardiomyopathy), exercise is accompanied by a smaller-than-normal decrease in end-diastolic left ventricular volume, depressed peak rates of left ventricular pressure rise and fall, and depressed heart-rate-dependent potentiation of contractility (bowditch treppe). We studied contractile function of isolated left ventricular myocardium ...

The current gold standard for prostate cancer treatment is androgen deprivation therapy and antiandrogenic agents. However, adverse cardiovascular events including heart failure can limit therapeutic use. Istaroxime, which combines Na+-K+-ATPase (NKA) inhibition with sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) stimulation, has recently shown promising anti-neoplastic effects in prostat...

Frequency potentiation of contractile function is a major mechanism of the increase in myocardial performance during exercise. In heart failure (HF), this positive force-frequency relation is impaired, and the abnormal left ventricular (LV)-arterial coupling is exacerbated by tachycardia. A myofilament Ca(2+) sensitizer, levosimendan, has been shown to improve exercise tolerance in HF. This may...

This paper presents the results of research of the microstructure of the composite blade W55RBVS for the wind turbine of up to 6kW power after structural testing up to failure. The first part of the testing consists of the static testing of the structure up to the moment of the blade failure. The aim of the first part of the test was to define rigidity of the blade W55RBVS, to determine the max...

α-Motor neurons receive synaptic inputs from spinal and supraspinal centers that comprise components either common to the motor neuron pool or independent. The input shared by motor neurons--common input--determines force control. The aim of the study was to investigate the changes in the strength of common synaptic input delivered to motor neurons with changes in force and with fatigue, two co...