Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the US and many western countries. It is well known that APAP induces mitochondrial damage to trigger centrilobular necrosis. Emerging evidence suggests that autophagic removal of damaged mitochondria may protect against APAP-induced liver injury. Electron and confocal microscopy analysis of liver tissues reveale...

The correct determination of deformation capacity of a structural member will become more important in the future since nonlinear design methods will be used more often. This report deals with the examination of deformation capacity of the concrete compression zone. The influence of size and the effect of transversal reinforcement of prisms under eccentric compression on their deformation capac...

Considering the structure effect of tunnel stability in western mining of China, three typical kinds of numerical model were respectively built as follows based on the strain softening constitutive model and linear elastic-perfectly plastic model for soft rock and interface: R-M, R-C(s)-M and R-C(w)-M. Calculation results revealed that the stress-strain relation and failure characteristics of t...

Mechanical failure is a characteristic of a material or device and not necessarily an indication of inadequacy. All devices will fail under some specific stress. It is only failure at the lowest levels of stress that may represent inadequacy. Stress on a material, for example, rises with strain until a critical load is exceeded, at which point the material fatigues and loses mechanical integrit...

This paper introduces a new technique which directly predicts the failure patterns of laterally loaded masonry panels based on the results of existing typical panels tested in the laboratory. The technique is based on the use of the cellular automata (CA). In this technique, the CA modelling is established to propagate boundary effects to zones within a panel. The corresponding rules for the st...

AIMS Implantable cardioverter defibrillators (ICDs) have shown to reduce all-cause mortality in heart failure patients. In SCD-HeFT study, ICDs were programmed with a detection zone of ≥ 187 b.p.m. Thus, the incidence and clinical significance of slower ventricular tachycardias (VTs) in these patients remains largely unknown, though clinically important for device selection, programming, and fo...

Grey zone in medicine and namely, in cardiology, represents a perplex area that clinicians have to navigate through and deal with. Grey cases in medicine represent intricate situations and the great challenge is to maneuver appropriately in order to narrow the grey zone and/or to move grey cases out of it. This may be achieved every so often by a comprehensive clinical approach, along with an e...

Due to the immense damage caused by dam failure, especially dams constructed near large cities, it is necessary to consider the breaking phenomena as well as studying and designing different parts of the dam. For this purpose, the hydrograph of the outflow due to dam failure must be identified according to size of the fracture and then flood routing, and flood zone must be determined based on t...

We studied the characteristics of an electrophysiological border zone detected after healing of experimental myocardial infarction in cats. Thirty-two isolated left ventricles were studied in tissue bath 2-7 months after distal left coronary artery ligation. Action potentials were recorded from endocardial ventricular muscle cells in normal, lateral border and central infarct zones. Action pote...