نتایج جستجو برای: family history fh
تعداد نتایج: 739379 فیلتر نتایج به سال:
Family history (FH) is an important indicator of a woman's future risk of developing breast cancer. Using data collected in a large population-based case-control study (6705 cases and 9341 controls), we examined the associations of breast cancer with known risk factors in women reporting a first-degree FH (mother or sister), with an emphasis on lifestyle determinants that may be altered to redu...
To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH(+)) or without (FH(-)) an FH of T2D. We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling...
AIM The present study aimed to evaluate the prevalence of positive family history of these cancers in a large population-based sample of Tehran province, capital of Iran. BACKGROUND Upper gastrointestinal (UGI) cancers (gastric and esophagus cancer) constitute a major health problem worldwide. A family history of cancer can increase the risk for developing cancer and recognized as one of the ...
Family history of alcohol dependence modulates functional neurophysiology in mood/anxiety disorders.
BACKGROUND A family history (FH) of alcohol dependence (AD) not only increases the risk for AD, but is also associated with an increased risk for mood and anxiety disorders. However, it is unknown how a FH of AD affects neural substrates in patients with mood and anxiety disorders. In this study we examined the effects of an alcoholic FH on cognitive and emotional functions in these patients us...
Age of onset (AO) has been proposed as a promising criterion by which to select homogeneous subgroups for the genetic analysis of bipolar disorder. This is the first study to investigate the effect of the interaction between gender and family history (FH)-type on AO in bipolar disorder. In accordance with the literature, no difference in AO was observed between females and males in our sample o...
Abstract Introduction Guidelines on the management of hereditary CRC were updated in 2019 and have led to more stringent use surveillance colonoscopies. Patients with ‘family history’ (FH) Surveillance programme at York Hospitals Trust studied assess compliance colonoscopy recommendations. Method Current BSG/ACPGBI guidelines recommend biennial, quinquennial, one-off or no for patients Lynch sy...
Familial hypercholesterolemia (FH) is associated with premature atherosclerotic cardiovascular diseases, and is inherited as an autosomal dominant trait. The prevalence of heterozygous FH is one in five hundred people. Owing to dysfunctional low density lipoprotein (LDL) receptors due to genetic mutations, serum low density lipoprotein-cholesterol (LDL-C) levels are considerably increased from ...
INTRODUCTION Youths with a family history of alcohol and other drug use disorders (FH+) are at greater risk of developing substance-use disorders relative to those with no such family histories (FH-). We previously reported that FH+ youths have elevated activity in the supplementary motor area (SMA) and dorsal striatum while performing go/no-go tasks and have reduced frontal white matter integr...
BACKGROUND Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed f...
Familial hypercholesterolaemia (FH) is an autosomal dominant genetic disorder, associated with significantly elevated levels of low-density lipoprotein cholesterol (LDL-C), and resulting in a 20-fold increased lifetime risk for premature cardiovascular disease. True prevalence of FH in the Russian Federation is unknown which leads to low percentage of diagnosed and treated cases. Research is ne...
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