In this article we develop a coalescent model with intralocus gene conversion. The distribution of the tract length is geometric in concordance with results published in the literature. We derive a simulation scheme and deduce a number of analytical results for this coalescent with gene conversion. We compare patterns of variability in samples simulated according to the coalescent with recombin...

If future electronic documents are to be truly useful, we must devise ways to automatically turn them into knowledge bases. In particular, we must be able to do this for diagrams. This paper discusses biological diagrams. We describe the three major aspects of diagrams: visual salience, domain conventions and pragmatics. We next describe the organization of diagrams into informational and subst...

Customers are overlooked often as a stakeholder group when it comes to assessing board performance. To gain insight into the factors that affect customer perceptions of non-profit board performance, over 20,000 members from 14 different professional, non-profit sporting clubs were surveyed. The results suggest that sporting club boards are evaluated primarily in line with perceptions specifical...

International measures to address environmental problems increasingly rely on scientific information, and a growing number of international agreements require periodic scientific re-assessments. However, the arena of scientific assessment, governed by a combination of scientific criteria and political interests, is not well-understood, and few case studies have mapped the influence of scientifi...

This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of...

MOTIVATION Many experimental and algorithmic approaches in biology generate groups of genes that need to be examined for related functional properties. For example, gene expression profiles are frequently organized into clusters of genes that may share functional properties. We evaluate a method, neighbor divergence per gene (NDPG), that uses scientific literature to assess whether a group of g...

While the published scientific literature is used in a biomedical context such as building gene networks for disease gene discovery, it seems to be an undervalued resource with respect to mental illnesses. It has been rarely explored for the purpose of gaining psychopathology insights. This limits our capability of better understanding the underlying mechanisms of mental disorders. In this pape...

chapters. Throughout the book, hemoglobin disorders are employed as a model of molecular pathology. Profusely illustrated, the volume will be invaluable for those seeking to become familiar with the basic concepts of molecular biology and its application to medicine, especially if, like me, you have had difficulty in following the scientific literature and words such as probes, gene cloning, ge...