Since the first frame-mounted fascia lata heart valves were used clinically (Ionescu and Ross, 1969), over 260 tissue valves made of autologous or homologous fascia lata or of heterologous pericardium have been inserted at this institution in the mitral, aortic, and tricuspid positions. Encouraged by our results, especially with aortic valve replacement, over more than four and a half years (Io...

Oxygen is necessary for maintaining cell proliferation and viability and extracellular matrix (ECM) production in 3-dimensional tissue engineering. Typically, diffusion is the primary mode for oxygen transport in vitro; thus, ensuring an adequate oxygen supply is essential. In this study, we determined the oxygen diffusion coefficients of 3 natural ECMs that are being investigated as construct ...

A large full-thickness chest wall defect over 10 cm in diameter requires skeletal reconstruction and soft tissue coverage. Use of various flaps for soft tissue coverage was previously reported, but en bloc resection in each case affects these flap pedicles and sizes. We present a case of a 74-year-old man with a soft tissue tumor involving the left lateral chest wall. We performed an en block r...

A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P<0 001). The collagen bundles were grossly disorganized and separated, suggesting a breakdown of the cross-linkage in the tissue. Redundant connective tissue on the surface of t...

We show that derived equivalences preserve the homotopy type of the (cohomological) Hochschild complex as a B∞-algebra. More generally, we prove that, as an object of the homotopy category of B∞-algebras, the Hochschild complex is contravariant with respect to fully faithful derived tensor functors. We also show that the Hochschild complexes of a Koszul algebra and its dual are homotopy equival...

Prosthetic cardiac valve replacement has been carried out at Brugmann University Hospital since 1962. In a series of 370 valvular replacements, operative and hospital deaths have attained a low rate (5%). The overall survival of 70% is comparable to that of most published series. Late thromboembolic complications, in spite of longterm anticoagulant therapy, remain the principal disadvantage of ...

HISTORY The optimal ACL reconstruction is still a highly demanding clinical issue in orthopaedic research. In vitro and in vivo studies highlight that pure single bundle ACL surgery is not completely able to functionally restore knee rotational stability patterns. In the past few decades, several surgical reconstructions, combining intraand extra-articular procedures, have been proposed with th...

Necessary and sufficient conditions are investigated for the existence of local bases in which the components of derivations of tensor algebras over differentiable manifold vanish in a neighborhood or only at a single point. The problem when these bases are holonomic or anholonomic is considered. Attention is paid to the case of linear connections. Relations of these problems with the equivalen...

Because there is no 'ideal' method for the complete correction of some of the more complex congenital cardiac abnormalities, a technique of making a composite graft of autologous fascia lata has been developed. Three types of grafts are described, all of them being based on the same general principle. The composite graft comprises a conduit, which serves to enlarge or reconstruct the outflow tr...