RATIONALE Chronic atrial fibrillation (cAF) is associated with atrial contractile dysfunction. Sarcomere remodeling may contribute to this contractile disorder. OBJECTIVE Here, we use single atrial myofibrils and fast solution switching techniques to directly investigate the impact of cAF on myofilament mechanical function eliminating changes induced by the arrhythmia in atrial myocytes membr...

The inactivation gating of hERG channels is important for the channel function and drug-channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and investigate hERG inactivation. By using whole cell patch clamp method with an internal solution cont...

Earlier difficulties have been observed in generating control sequences for prosthesis as well as other applications when using biological signals such as EEG. This paper deals with a new methodology of using EEG and discriminating between close/open state of the eyes. Digitized signal of duration 3 seconds had been divided into 8 segments and a digital band pass (BP) filter (Butterworth) imple...

[no abstract available]

1. In mo9t isolated gastropod nervous systems, presumed feeding motor patterns are thought to be represented by the alternating motor activity in buccal roots, which underlies rhythmic radula movement. Since this movement accompanies several types of behaviour in the gastropod Pleurobranchaea (McClellan, 1979, 1980, 1982), the presumed feeding motor activity in the isolated nervous system of th...

Postsynaptic inhibition is a key element of neural circuits underlying behavior, with 20-50% of all mammalian (nongranule) neurons considered inhibitory. For rhythmic movements in mammals, e.g., walking, swimming, suckling, chewing, and breathing, inhibition is often hypothesized to play an essential rhythmogenic role. Here we study the role of fast synaptic inhibitory neurotransmission in the ...