Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was genotyped in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate...

OBJECTIVES To evaluate the clinical significance of body fat distribution in childhood obesity, we investigated the associations of subcutaneous and intraabdominal (preperitoneal and visceral) fat, estimated by ultrasonography, with metabolic risk factors. SUBJECTS Fifty-one obese (age 11.5+/- 2.6 years) and 33 non-obese (age 12.2+/- 2.7 years) children. STUDY DESIGN Case control study. M...

Introduction. The study of fat distribution is important to understand the pathophysiology of obesity-related disorders, diabetes mellitus and cardiovascular diseases. Excessive accumulation of fat in liver, muscle and abdomen are known to reduce insulin sensitivity [1-3]. Several studies have also suggested that the fat distribution is different across different ethnic groups [2-3]. In this st...

We investigated sex- and menopause-related differences in body composition and regional fat distribution, using dual-energy X-ray absorptiometry (DEXA) in nonobese healthy volunteers. Men (n = 103) had a 50% greater lean tissue mass (P less than 0.001) but a 13% lower fat mass (P less than 0.001) than the women (n = 131). Postmenopausal (n = 70) women had a 20% greater fat mass (P less than 0.0...

.............................................................................................................................. ii Co-Authorship Statement................................................................................................... iii Acknowledgments.............................................................................................................. iv Table of Co...

PURPOSE To reliably compensate bias field effects in abdominal areas to accurately quantify visceral adipose tissue using standard T1-weighted sequences on MR scanners with up to 3 Tesla (T) field strength. MATERIALS AND METHODS Compensation is achieved in two steps: The bias field is first estimated by picking and fitting sampling points from the subcutaneous adipose tissue, using active con...

OBJECTIVE Differential meal fat uptake into adipose tissue depots may be a determinant of body fat distribution. RESEARCH DESIGN AND METHODS We used the meal fat tracer/adipose tissue biopsy approach to compare the effects of meal fat content on the fat uptake into visceral and upper and lower body subcutaneous fat depots in 21 premenopausal women. [(3)H]triolein was used to trace the fate of...

Body fat distribution is an important predictor of metabolic abnormalities in obese humans. Dysregulation of free fatty acid (FFA) release, especially from upper body subcutaneous adipose tissue, appears to contribute substantially to these metabolic disturbances. Why different individuals preferentially store fat in upper vs. lower body subcutaneous fat or subcutaneous vs. visceral fat is not ...