background: hemorrhagic transformation (ht) of ischemic stroke (is) is a detrimental complication. this study investigated the association between serum ferritin level and ht in patients with massive is of middle cerebral artery.   methods: thirty patients with massive is of middle cerebral artery were enrolled in this prospective cohort study. they were divided into two groups based on the ser...

background: increased estimated body iron stores have been recently suggested to be associated with increased risk of acute myocardial infarction (ami); however the question of whether serum ferritin level as an indicator for estimating body iron is an independent risk factor for cardiac events is still questioned. in the present study, we assessed whether serum ferritin was associated with the...

background febrile seizures (fs) are the most common type of convulsion in young children. the predisposing factors are still under investigation; however, iron insufficiency might play a role in this regard. objectives our objective was to determine the association between iron status and febrile seizure. patients and methods this prospective case-control study was conducted among 109 children...

Aims: Chronic diseases strongly affect the severity of infection and mortality in patients with COVID-19. High levels of ferritin also indicate the severity of the disease and may indicate the presence of secondary infections among patients. The aim of this study was to compare ferritin levels in diabetic patients with COVID-19 and non-diabetic patients with COVID-19 based on age and gender gro...

The serum ferritin concentration is a clinical parameter measured widely for the differential diagnosis of anemia. Its levels increase with elevations of tissue iron stores and with inflammation, but studies on cellular sources of serum ferritin as well as its subunit composition, degree of iron loading and glycosylation have given rise to conflicting results. To gain further understanding of s...

Ferritin is highly expressed in many cancer types. Although a few studies have reported an association between high serum ferritin levels and an increased risk of prostate cancer, the results are inconsistent. Therefore, we performed a large case-control study consisting of 2002 prostate cancer patients and 951 control patients with benign prostatic hyperplasia (BPH). We found that high ferriti...

Biofortification is a strategy for combating iron deficiency that involves the selectivebreeding of food crops to increase total bioavailable iron. Evidence showing ferritin as agood source of bioavailable iron has created interest for enhancing ferritin content in seeds.However, the successful implementation of ferritin biofortification requires a method torapidly measure ferri...

OBJECTIVE The aim of the present work was to verify whether adenoviral vector mediated ferritin over-expression in mesenchymal stem cells could be detected by 7T MRI device, and to explore the relationship between ferritin content and MRI signal intensities. METHODS A recombined adenoviral vector (rAdV) encoding ferritin heavy chain (FTH1) subunit was specially designed for the aim of infecti...

BACKGROUND Efforts to develop global programs for the control of iron deficiency require simple, low-cost, and accurate indicators of iron status. OBJECTIVE We aimed to compare estimates of body iron (BI) stores, as calculated from either plasma ferritin concentration alone (BI-ferritin) or the ratio of plasma transferrin receptor (TfR) to ferritin (BI-TfR/ferritin). DESIGN Data were analyz...

Ferritin has gained significant attention as a potential reporter gene for in vivo imaging by magnetic resonance imaging (MRI). However, due to the ferritin ferrihydrite core, the relaxivity and sensitivity for detection of native ferritin is relatively low. We report here on a novel chimeric magneto-ferritin reporter gene - ferritin-M6A - in which the magnetite binding peptide from the magneto...