cyproterone acetate (ca) has been loaded to liposome by solvent evaporation and thin film formation technique. the effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. the data showed that bigger balloon with higher surface area has b...

although some vitamins have been shown to prevent glucocorticoids induced osteoporosis in short time, the magnitude of this effect remains to be clarified. the aim of this study was to evaluate protective effect of vitamin d3 on methylprednisolone acetate (mpa) induced osteoporosis in rats. twenty-four male sprague dawley rats were randomly divided into four groups: group a (n = 6), was a base ...

chemical composition of the essential oils extracted from the leaves, stems, flowers and seeds of  heracleum rechingeri manden. were analyzed by gc and gc/ms. twenty-four components were characterized for the leaf oil with octyl acetate(47.2%), octanol(15.2%) and e-caryophyllen (5.7%) as the main constituents. 25 compounds were identified in the stem oil with elemicin (65.3%), octyl acetate (13...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

the multivariate calibration method, partial least square regression (pls) was applied for thesimultaneous spectrophotometric determination of lidocaine (lid) and hydrocortisone acetate(hca) in their mixtures. the parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...

pregnancy prevention raises much concern to many pet owners. female cats usually show undesirable behaviour during oestrus. nowadays, researchers try to explore the reliable and effective ways to prevent oestrus signs in queens. the results of their studies prove that hormone therapy is probably one of the most reliable methods for this purpose. the aim of our study was to compare the effect of...

objective: the immunomodulatory effect of geranial, geranial acetate, gingerol, and eugenol essential oils were evaluated by studying humoral and cell-mediated immune responses. materials and method: the essential oils were evaluated for immunomodulatory activity in in vivo studies, using rats as the animal model. the essential oils were tested for hypersensitivity and hemagglutination reaction...

conclusions ferulago angulata extract, because of its antioxidant activities, is probably capable of removing free radicals and oxidant substances from brain and thus it can improve behavioral disorders in brain hypoperfusion ischemia model. results it was found that the administration of 400 mg/kg hydroalcoholic extract of f. angulate for two weeks after brain hypoperfusion ischemia increased ...

Leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of Leishmania species and makes enormous mortality and morbidity. There are clues of antileishmanial effects of prenylated coumarins. Apiaceae family is one of the most important sources of coumarins. Air-dried aerial parts of Ferulago angulata and fruits of Prangos asperula were extracted with n-hexane, using a...