BACKGROUND Anthracyclines are essential for the treatment of malignancies observed in pregnant patients. Knowledge of the potential side-effects of chemotherapy on the developing fetus is essential for patient counseling. PATIENTS AND METHODS We collected information concerning patients treated with anthracyclines during pregnancy from a review of literature between 1976 and 2001 and our expe...

A possible detrimental paternal age effect on offspring health due to mutations of paternal origin should be reflected in an association between paternal age and fetal loss. The authors used data from a prospective study of 23,821 pregnant women recruited consecutively to the Danish National Birth Cohort from 1997 to 1999 to assess the association between paternal age and fetal death. Fathers o...

Case 1: A 24 year old woman (G 1, P 0, Ab 0) delivered a 2500 gram stillborn male fetus at term. Her prenatal care record was negative for factors associated with high risk pregnancy. No infections were diagnosed during the prenatal period. Case 2: A 22 year old woman (G 1, PO, Ab 0) delivered a 514 gram stillborn macerated female fetus at nineteen weeks gestation. Her antepartum course was com...

A second trimester fetal demise followed influenza-like illness in early pregnancy. Influenza A virus (H1N1) was identified in maternal and fetal tissue, confirming transplacental passage. These findings suggested a causal relationship between early exposure and fetal demise. Management of future influenza outbreaks should include evaluation of products of conception associated with fetal loss.

OBJECTIVE To examine in monochorionic pregnancies the possible value of intertwin discordance in nuchal translucency (NT) thickness in the prediction of early fetal death or severe twin-twin transfusion syndrome (TTTS). METHODS In 512 monochorionic twin pregnancies NT was measured at 11 to 13 + 6 weeks' gestation and regression analysis was used to determine the significance of the associatio...

BACKGROUND Hyperthermia acts as a teratogen in some animals where it can induce resorption of the fetus and fetal death. Fever during pregnancy, especially in the period of embryogenesis, is also suspected as being a risk factor for fetal death in human beings. We did a large cohort study in Denmark to investigate this possibility. METHODS We interviewed 24040 women who were recruited in the ...

The fetal risk in maternal diabetes mellitus is high [5, 6]. The reasons for fetal macrosomatia are controversially as are those for intrauterine fetal growth retardation and intrauterine fetal death. These mostly happen without prodromes and are feared by all obstetricians. Morphologists have described signs of a so-called chronic placental insufficiency in cases of small for date infants and ...

BACKGROUND Intrahepatic cholestasis of pregnancy is associated with an increased risk of fetal death. The mechanism of death is unknown. CASES The first case involved a young primipara with pruritus and a bile acid concentration of 79 mumol/dL. While undergoing fetal heart rate monitoring, the fetus had a prolonged deceleration resulting in intrauterine death. The second case involved a young...