Diurnal patterns of plasma euglobulin fibrinolytic activity, estimated by the fibrin plate method, were determined in groups of young normal and older normal subjects, in subjects with type IV hyperlipoproteinemia, and in subjects with coronary artery disease who had normal lipid profiles. The marked diumal increases in fibrinolytic activity observed in the young normal subjects were significan...

A semi-automatic method for the routine evaluation of fibrinolytic activity is described. The principle is based upon graphic recording by a multichannel voltmeter of tension drops over a potentiometer, caused by variations in the influence of light upon a light-dependent resistance, resulting from modifications in the composition of the fibrin fibres by lysis. The method is applied to the asse...

]n the thronibogenic theory of the pathogenesis of arteriosclerotic lesions, parietal fibrin deposits in the arteries play a primary role. In an effort to elucidate the heinostatic system in the arterial wall, the thromboplastic activity and the fibrinolytic activity (estimated as plasminogcn activator) in the layers of the human aorta have been estimated. The simultaneous presence of high thro...

Antithrombotic and fibrinolytic activity of natto was evaluated on platelet aggregation in vitro and in vivo. Natto showed inhibitory effects on platelet aggregation induced by adenosine 5'diphosphate (ADP) and collagen. Orally administered natto also showed fibrinolytic activity in hypercholesterolemia rats. Normal levels of natto, when administered for four weeks, shortened euglobulin clot ly...

By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...

For the future treatment of ST-elevation myocardial infarction, fibrinolytic therapy will be the most widely used therapy, because of its simplicity, worldwide availability and relatively low cost. In comparison to primary angioplasty, which will continuously be hampered by its limited availability and inherent time delay, fibrinolytic therapy has two major drawbacks: partial efficacy and a sma...

A systematic investigation of the fibrinolytic system during the period after acute myocardial infarction in 42 patients showed a progressive reduction of fibrinolytic activity, with the longest lysis times on days 4 to 5 after the event. There is a concomitant rise in the levels of fibrinogen, plasminogen, and antiplasmin; only the latter parallels the delay in lysis. After 12 to 15 months, no...

By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...

The rate of digestion of fibrin was measured in vitro by an isotopic technique in 140 blood samples of differing fibrinogen concentration; the assessment of fibrinolytic activity thus obtained was compared with a standard method of measurement, the dilute whole blood lysis time. The lysis time was related exponentially to the fibrinolytic activity as measured by the isotopic technique, and furt...

Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125l-fibrinlabeled thrombi in rabbit jugular veins at different times after a bolus injection of the fibrinolytic agents. T...