BACKGROUND Altered intestinal function is prevalent in patients with heart failure (HF), but its role in adverse outcomes is unclear. OBJECTIVES This study investigated the potential pathophysiological contributions of intestinal microbiota in HF. METHODS We examined the relationship between fasting plasma trimethylamine-N-oxide (TMAO) and all-cause mortality over a 5-year follow-up in 720 ...

objective: diabetic nephropathy is a major diabetes complication. arterial resistance index (ri) may predict deterioration in kidney function. this study was designed to compare renal arterial ri in different stages of renal function according to glomerular filtration rate (gfr), serum creatinine level and proteinuria. materials and methods: in a cross-sectional study on 81 diabetic patients in...

OBJECTIVE To investigate the role of intrarenal vascular disease in the pathogenesis of nonalbuminuric renal insufficiency in type 2 diabetes. RESEARCH DESIGN AND METHODS We studied 325 unselected clinic patients who had sufficient clinical and biochemical information to calculate an estimated glomerular filtration rate (eGFR) using the Modified Diet in Renal Disease six-variable formula, at ...

A polypropylene microporous membrane (PPMM) was fabricated by thermally induced phase separation (TIPS) method. The effects of protein size and structure as well as filtration pressure on the membrane performance and fouling mechanisms were investigated using two different proteins, bovine serum albumin (BSA) and collagen, in dead-end filtration setup. Obtained results showed that, for each pro...

OBJECTIVES Amphotericin B (AmB) is a drug of choice for treatment of disseminated fungal infections, but its use is often associated with severe adverse effects. Our observation that generic formulations of AmB contain multiple polyene components led us to propose that removal of other polyenes would yield a high purity AmB (AmBHP) with an improved therapeutic index. METHODS To test that prem...

BACKGROUND The association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and acute or chronic renal failure is well documented, but evidence of such association between NSAIDs and Contrast-Induced Nephropathies (CIN) is not found in the indexed literature. OBJECTIVE To evaluate the possible association between NSAIDs and CIN. METHODS In a cohort study, through clinical in...

Glomerular filtration rate (GFR) is still a highly underutilized tool in cats because available methods are not easy to be performed in clinical practice. Iohexol (IOX) has been shown to be a useful and reliable marker of GFR both in animals and in humans. The aim of the present study was to develop a rapid and reliable method for measuring IOX in feline plasma and to evaluate the accuracy of l...

1. The associations between the renal clearance of ingested lithium (used as a marker of renal proximal tubular sodium handling) and a number of biological variables have been investigated in an unselected sample of 592 healthy and untreated white men (aged 21-68 years) under their usual living conditions and drawn from a population at work. 2. Renal excretion of lithium was expressed both as c...

BACKGROUND Accurate glomerular filtration rate (GFR) measurement in normal to high range is important for epidemiological studies and workup for kidney donation. Creatinine-based equations perform poorly in this GFR range. Creatinine clearance (CrCl) provides a substitute, provided urine is collected accurately and tubular creatinine handling can be accounted for. The latter is poorly character...