Objective(s):Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. But the effect of berberine on breast cancer has not yet been completely studied. In this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. Materials and Methods: The antiproliferative effects of berberine and doxorubicin alone and in ...

rheum turkestanicum janischew. (polygonaceae) is a plant that grows in central asia and in north-east of iran. traditionally, people use roots of r. turkestanicum as an anti-diabetic and anti-hypertensive as well as anticancer agent. in this study the cytotoxicity and apoptogenic properties of ethyl acetate (etoac), n-hexane and h2o extracts from rheum turkestanicum janischew. (polygonaceae) ro...

intraplatelet phospho-vasp analysis is a commonly used approach for monitoring of anti-platelet therapy; however, testing of intraplatelet phospho-vasp expression needs a high level of experience and proficiency. the ability to recognize how the pre-analytical variations can change the results would be helpful for the interpretation of data from intraplatelet p-vasp analysis. the aim of this st...

background :   chitosan is unbranched polysaccharide composed of d-glucosamine and n-acetyl-d-glucosamine. chitosan, derived from shrimp shell, has broad antimicrobial properties against gram-negative, gram-positive bacteria and fungi.   methods :  chitosan was extracted from shrimp shell and studied for cell entrapment and anti-bacterial properties. the hydrogel chitosan was used as the beads ...

conclusions this study delineated the beneficial role of rsv for growth regulation of skin cancer cells and highlighted the involvement of rsv in the induction of apoptosis in a431 cells. these findings might conduct evidence into the oncolytic properties of rsv in the skin cancer. further studies are required to indicate intracellular targets for rsv-induced apoptosis in skin cancer cells. res...

introduction: acute leukemia is the most common malignancy in children and acute lymphoblastic leukemia (all) accounts for 75% of acute leukemia cases. new treatment protocols have resulted in complete remission rates up to nearly 100% in children with acute lymphoblastic leukemia. today, one of the most important prognostic factors in acute lymphoblastic leukemia is intensity of the treatment....

background: differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. objective: we analyzed the nuclear dna content of various types of hydropic placentas by flowcytometry. materials and methods: dna ploidy analysis was performed i...

objective: biebersteinia (geraniaceae) has a history of use in traditional medicine in some countries including iran. in the present study, cytotoxic and apoptogenic properties of hydro-ethanol extract of b. multifidi was investigated on human prostate cancer cell lines (pc3 and du 145) and human embryonic kidney 293 (hek293) cells. materials and methods: cells were cultured in rpmi-1640 medium...

salvia chorassanica bunge is one of the iranian endemic species of salvia. there is not any reported literature on s. chorassanica. this study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of s. chorassanica and its fractions on hela cell line. cells were cultured in ex-cell®, an animal free medium specially designed for hela cell line ...

Background: Hair follicle stem cells (HFSCs) located in the bulge area has shown to be highly proliferative and could differentiate into neurons, glia, smooth muscle cell, and melanocytes in vitro. Simvastatin is an HMG-CoA reductase inhibitor that exerts pleiotropic effects beyond simple low-density lipoprotein lowering and has a similar impact on the differentiation of bone marrow stromal cel...