Macrophage colony-stimulating factor ((SI -I i increases the tissue invasive potential of the CSF-1 receptor-bearing lung carcinoma cell lines A549 and Calu-1 by increasing the number of endogenous!) bound urokinase-type plasminogen activators (u-PA)s on these cells. CSF-1, at concentrations which optimize invasion of A549 and Calu-1 cells into human amnion membranes (250 ng/ml), maximally augm...

We present a discrete element model for simulating, at the grain scale, gas migration in brine-saturated deformable media. We rigorously account for the presence of two fluids in the pore space by incorporating forces on grains due to pore fluid pressures, and surface tension between fluids. This model, which couples multiphase fluid flow with sediment mechanics, permits investigating the upwar...

Interstitial fluid flow and associated shear stress are relevant mechanical signals in cartilage and bone (patho)physiology. However, their effects on chondrosarcoma cell motility, invasion and metastasis have yet to be delineated. Using human SW1353, HS.819.T and CH2879 chondrosarcoma cell lines as model systems, we found that fluid shear stress induces the accumulation of cyclic AMP (cAMP) an...

Macrophage colony-stimulating factor (CSF-1) increases the tissue invasive potential of the CSF-1 receptor-bearing lung carcinoma cell lines A549 and Calu-1 by increasing the number of endogenously bound urokinase-type plasminogen activators (u-PA)s on these cells. CSF-1, at concentrations which optimize invasion of A549 and Calu-1 cells into human amnion membranes (250 ng/ml), maximally augmen...

Macrophage colony-stimulating factor ((SI -I i increases the tissue invasive potential of the CSF-1 receptor-bearing lung carcinoma cell lines A549 and Calu-1 by increasing the number of endogenous!) bound urokinase-type plasminogen activators (u-PA)s on these cells. CSF-1, at concentrations which optimize invasion of A549 and Calu-1 cells into human amnion membranes (250 ng/ml), maximally augm...

The brain is well protected against microbial invasion by cellular barriers, such as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells within the central nervous system (CNS) are capable of producing an immune response against invading pathogens. Nonetheless, a range of pathogenic microbes make their way to the CNS, and the resulting infections ...

Staphylococcus caprae strain 9557 was isolated from a cerebrospinal fluid sample. The assembled genome contained 2,747,651-bp nucleotides with 33.34% GC content. Consistent with its phenotypic characteristics, the genome harbors a varying repertoire of putative virulence factors involved in invasion, survival, and growth in the host cells.

1. The pathology of the experimental dermal pneumococcic infection in the rabbit is described in detail and the findings are compared with the histological alterations seen in the human pneumonic lung. There would appear to be a basic similarity of the lesions in both tissues. 2. A copious production of edema fluid is the outstanding characteristic of the early lesion. It occurs prior to any si...

The invasion of Spartina alterniflora significantly affected the local ecosystem of Western Pacific Ocean where Moerella iridescens lives. Five patches with different invasion stages of S. alterniflora were selected and the influence on distribution of M. iridescens was studied on the coast of Wenzhou Bay, China in 2007. The aggregated distribution pattern was proved by using Taylor&#39s power ...

Endothelial cells are subjected to biochemical and mechanical stimuli, which regulate their angiogenic potential. We determined the synergistic effects of sphingosine-1-phosphate (S1P) and fluid wall shear stress (WSS) on a previously established model of human umbilical vein endothelial cell invasion into three-dimensional collagen matrices. Collagen matrices were incorporated into a parallel-...