نتایج جستجو برای: fluorination treatment
تعداد نتایج: 1395580 فیلتر نتایج به سال:
A new reaction for the rhodium-catalyzed geminal-difunctionalization-based fluorination is presented. The substrates are aromatic and aliphatic diazocarbonyl compounds. As the fluorine source a stable and easily accessible benziodoxole reagent was used. A variety of alcohol, phenol, and carboxylic acid reagents were employed to introduce the second functionality. The reaction was extended to tr...
Water-protein interactions dictate many processes crucial to protein function including folding, dynamics, interactions with other biomolecules, and enzymatic catalysis. Here we examine the effect of surface fluorination on water-protein interactions. Modification of designed coiled-coil proteins by incorporation of 5,5,5-trifluoroleucine or (4S)-2-amino-4-methylhexanoic acid enables systematic...
Although extensive theoretical and experimental research has been conducted on fluorinated fullerenes, little detailed information exists on their solubility in different solvents. However, this solubility is crucial for their processability and possible application. In this work, we predict the solubility of fluorinated C(60) in various polar and non-polar solvents, based on a correlation betw...
We offer a mild, metal-free sp(3) C-H fluorination alternative using Selectfluor and a substoichiometric amount of triethylborane--an established radical initiator in the presence of O2. This radical-chain-based synthetic method is particularly noteworthy as an offspring of the insight gained from a mechanistic study of copper-promoted aliphatic fluorination, constructively turning O2 from an e...
The direct conversion of aliphatic carboxylic acids to the corresponding alkyl fluorides has been achieved via visible light-promoted photoredox catalysis. This operationally simple, redox-neutral fluorination method is amenable to a wide variety of carboxylic acids. Photon-induced oxidation of carboxylates leads to the formation of carboxyl radicals, which upon rapid CO2-extrusion and F(•) tra...
Fluorinated organic compounds have a long history in medicinal chemistry, and synthetic methods to access target fluorinated compounds are undergoing a revolution. One powerful strategy for the installation of fluorinecontaining functional groups includes decarboxylative reactions. Benefits of decarboxylative approaches potentially include: 1) readily available substrates or reagents 2) mild re...
یکی از مهمترین دست آوردهای تکنولوژی غذایی، تصفیه شکر از نیشکر و چغندر بوده است. بین سال های ۱۸۷۰ و ۱۹۱۰، شکر یک ماده غذایی ارزان قیمت شد و به خاطر شیرینی، در دسترس بودن به اشکال مختلف و مفید بودن به عنوان یک ماده غذایی قابل نگهداری به خوبی مورد قبول واقع شد. ولی نتیجه بعدی و ناشناخته این دسترسی آسان به شکر، افزایش خرابی و پوسیدگی دندانها بود. بررسی های اپیدمیولوژیکی نشان داد که تا سال های ۱۹۳۰ ...
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