BACKGROUND Delirium in older adults is a common and serious acute neuropsychiatric syndrome, with core features of inattention and global cognitive impairment. Although antipsychotic drugs are the medications most frequently used to treat this syndrome, these drugs are associated with a variety of adverse events, including sedation, extrapyramidal side effects, and cardiac arrhythmias. METHOD...

In a prospective, non-blinded, uncontrolled, multicenter, post-marketing, observational study (FRIENDS; NCT02043197), fluvoxamine (50-300 mg/day for 90 days) was effective for the treatment of depression in 299 adult patients (age ≥18 years) with neurological disorders at baseline. The therapeutic effect of fluvoxamine was measured by means of changes in the Hospital Anxiety and Depression Scal...

Corresponding author: Ali Alavi, Child and Adolescent Psychiatrist, Department of Child and Adolescent Psychiatry, Roozbeh Hospital, South Kargar Ave., Tehran, Iran. email: [email protected] Tel: +98-917-3055282 Objective: Major depressive disorder is a severe disorder that has a significant impact on the psychological and social functioning of children and adolescents. Considering current...

Kobayashi and associates recently reported that CYP2E1 is the major low-affinity phenacetin O-deethylase in human liver microsomes using a combination of chemical inhibition and correlation studies on human liver microsomes, and kinetic studies on recombinant human cytochromes, heterologously expressed in insect cells using a baculovirus expression system (Kobayashi et al., 1999). We previously...

Objective: Although treatments with demonstrated efficacy exist for Obsessive-compulsive disorder (OCD); researches on the effectiveness of combined treatment versus psychotherapy or drug treatment are controversial. The aim of this study was to compare the efficacy of Metacognitive therapy (MCT), fluvoxamine and the combination of MCT with fluvoxamine treatment in treating patients with OCD. M...

Serotonin (5-hydroxytryptamine; 5-HT) is known to be activated during ischemia-reperfusion and triggers contractile dysfunction and pathological apoptosis. Here, the beneficial effects of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine was demonstrated on ischemia-reperfusion injury in guinea-pig hearts perfused using the Langendorff technique. The recovery (%) of left ventricular...

Several techniques are used to increase the aqueous solubilities of poorly water soluble drugs. Hydrotropic solubilization technique is one of them. In the present investigation hydrotropic solution of Urea (10M) has been used as a solubilizing agent to solubilize poorly water soluble drug. Fluvoxamine maleate shows maximum absorbance at 271 nm. Beer’s law was obeyed in the concentration range ...