Neoplasms and (non-neoplastic) focal dysplasias may coexist as a cause of seizures in both the developing and mature brain. Low grade neoplastic lesions (ganglioglioma/gangliocytoma) may present with seizures, and distinction of these lesions from focal cortial dysplasia is difficult on standard radiological imaging. We report a 24-year-old man who had complaints of tonic-clonic seizures for on...

Introduction: Patients who present for treatment of alcohol dependence often report a history of seizures. These are generally attributed to alcohol withdrawal and not further investigated. Methods: We systematically assessed 381 consecutive male inpatients with alcohol dependence admitted to the deaddiction services of the National Institute of Mental health & Neurosciences (NIMHANS), Bangalor...

Four patients with metastatic brain disease were referred for computed tomographic (CT) examination with contrast material injection. Within 2 to 4 minutes after the intravenous administration of water soluble contrast agent, focal epileptic activity occurred. The seizures became generalised in two of the patients who later died following status epilepticus. In the other two patients the focal ...

To evaluate the etiological profile of new onset focal seizures in adults with the help of neuroimaging studies, Immunological methods in a tertiary care hospital in Chennai. 50 Cases of new onset focal seizures were included in the study. The etiology was determined by neuroimaging and appropriate investigations were done. In the age group of 18-70 yrs maximum cases were seen between 18-30 yrs...

OBJECTIVES Little is known about the long term outcome of patients with periventricular nodular heterotopia (PNH) and epilepsy, particularly the course of seizures. This study investigated the electroclinical and prognostic features of 16 patients with PNH. METHODS Of 120 patients with epilepsy and malformations of cortical development, 16 had PNH. Of these, eight patients had periventricular...

• We visualized the phase-amplitude coupling phenomenon related to seizures by showing rhythmic fluctuation of high-frequency activities. The low frequency band mainly coupled ictal-ripple activities was θ (4–8 Hz). seizure-related ripple power started increase, and then spread, with fluctuations, not linear increases. High-frequency (HFAs) (PAC) are key neurophysiological biomarkers for studyi...

Mechanisms underlying focal motor seizures and the Jacksonian "march" have been explored on the basis of recent physiologic data concerning the "nested ring" spatial and functional organization of motor cortex. Focal motor seizures can be understood in terms of the focal representation at motor cortex of elements controlling movement of a limb part about a single joint. The preponderance of thr...

Eslicarbazepine acetate (Zebinix®, ESL), a voltage-gated sodium channel blocker, is once-daily, orally administered anti-seizure medication available in the EU for use as monotherapy adults with newly diagnosed partial-onset seizures and adjunctive therapy adults, adolescents, children aged > 6 years seizures. It was approved by European Medicines Agency launched onto market 2009.
 This...

Fourteen children with various seizure disorders were studied using a cerebral blood flow tracer, 123I iodoamphetamine (0.05 mCi/kg), and single photon emission computed tomography (SPECT). In the five patients with radiological lesions, SPECT showed congruent or more extensive abnormalities. Five of the nine children with a normal scan on computed tomography had abnormal SPECT studies consisti...

Focal epilepsy involves excessive and synchronous cortical activity that propagates both locally and distally. Does this propagation follow the same routes as normal cortical activity? We induced focal seizures in primary visual cortex (V1) of awake mice, and compared their propagation to the retinotopic organization of V1 and higher visual areas. We measured activity through simultaneous local...