in order to identify the effects of vitamin b 12 and folic acid in reducing methanolinduced retinopathy, erg waves were compared before and after methanol intoxication in rabbits. in this study 34 rabbits were divided into 4 groups. all groups received 4 g/kg of methanol intraperitoneally. in addition, the second, third and fourth groups received vitamin b 12 injection, oral folic acid and a mi...

Periconceptual consumption of folic acid has been shown to decrease the incidence of neural tube defects. The strategy of universal fortification of staple foodstuffs with folic acid presents the possibility of life-long exposure to unmetabolized folic acid. Chief among the risks of exposure to folic acid in the circulation is that of masking the diagnosis of cobalamin deficiency in pernicious ...

INTRODUCTION Neural tube defects are congenital malformations of brain and spinal cord. There is evidence that adequate amounts of folic acid supply to women before and during early pregnancy decreases the risk of having a neural tube defects affected child. Main sources of folic acid are food rich in folic acid, multivitamins with folic acid supplementation, and folic acid fortification of cer...

Folic acid (pteroylmonoglutamic acid) is the stable, fully oxidized form of folate which is used in food fortification and supplements. Keen interest has been generated in folic acid due to its suggested role in prevention of various disorders. Strong evidence from clinical trials indicates preventive effect of folic acid on both occurrence and recurrence of neural tube defects. It also plays a...

BACKGROUND Synthetic folic acid (0.4-1.0 mg) consumed during the periconceptional period has been shown to reduce the risk of neural tube defects. Women with poor supplement adherence or a previous pregnancy affected by a neural tube defect may need to take higher doses of folic acid (4-5 mg). However, there are limited data on the pharmacokinetics of higher folic acid doses. OBJECTIVE Our ai...

Background and Aim: Vitiligo is a hypopigmentation disorder of the skin that is associated with depression and an impaired quality of life. There has been conflicting reports on the association between the disease and the serum levels of homocysteine, vitamin B12, and folic acid.In this study,serum levels of homocysteine, vitamin B12, and folic acid were evaluated in patients with vitiligo.Meth...

QUESTION Now that flour and pasta have been fortified with folic acid in Canada, do I still need to recommend folic acid supplements to my patients who are of child-bearing age? If I should recommend supplements, when should I recommend them, and what is an appropriate dose? ANSWER Non-pregnant women should consume 400 microg of folic acid daily, and pregnant women should consume 600 microg o...

BACKGROUND Supplementation with B vitamins for stroke prevention has been evaluated over the years, but which combination of B vitamins is optimal for stroke prevention is unclear. We performed a network meta-analysis to assess the impact of different combinations of B vitamins on risk of stroke. METHODS A total of 17 trials (86 393 patients) comparing 7 treatment strategies and placebo were ...

background: previous studies have reported the antifertility activities of sulfonamides. this study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats. methods: a total of 54 rats were randomly divided into 9 groups (n=6) . group i served as the control and group ii (vehicle) received saline. other groups, iii to ix,...

l-tyrosine, b6 and folic acid are involved in biosynthesis of dopa and consequently dopamine. the aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. a significant decrease in m...