Abstract Ibrutinib is a drug used for the treatment of marginal zone lymphoma, mantle cell lymphocytic leukemia, chronic graft, and Waldenstrom macroglobulinemia. A simple, sensitive, fast liquid chromatographic spectrophotometric method quantification ibrutinib in pharmaceutical forms bulk was developed validated. The technique using an ODS 3 C 18 (250 mm × 4.6 i.d., 5 µm) column. mobile phase...

a total of 1440 arian chicks were used in this study to determine the effects of diet formulation methods on performance and blood parameters of arian chicks. eight diets were arranged in a 2×2×2 factorial design with 2 methods of energy expression (apparent (amen) and true (tmen) metabolizable energy corrected to n equilibrium), 2 methods of amino acids content of feeds (total (taaf) and diges...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...