Copyright © 2010 Frederick Furness Publishing 16 A focus on enzyme replacement therapies (ERT) for lysosomal storage diseases has led Shire Human Genetic Therapies, Inc (Shire HGT) to develop products for treating Fabry disease, Hunter syndrome, and type 1 Gaucher disease. These products are administered intravenously (IV) and are effective in treating the somatic symptoms of the disease. Devel...

Mixed integer programming (MIP) formulations are typically tightened through the use of a separation algorithm and the addition of violated cuts. Using extended formulations involving new variables is a possible alternative, but this often results in prohibitively large MIPs where even the linear programming relaxations are hard or impossible to solve. In this paper, we demonstrate how, in cert...

Abstract Kermanshah is a city in west of Iran with a specific customs and cultures between the Kermanshah is a city in west of Iran with a specific customs and cultures between the people who are living here. According to historical documents these cultures are very ancient and belong to more than one thousand years. The climate condition in this place forces people to find the solution of thei...

Business rules are generally expressed in natural language, although some rules are at times illustrated graphically. SBVR is not a logic language for restating business rules in some other language that business people don’t use. Rather, SBVR provides a means for describing the structure of the meaning of rules expressed in the natural language that business people use. SBVR calls this “semant...

FETI 205 A conforming FEM for (2.7) results in the discrete optimality system   K1 0 B T 1 0 0 K̃2 −B2 −C2 Υ B1 −B2 0 0 0 −ΥC2 0 Υ     u1 u2 λ μ   =   f1 f2 0 0   (2.8) where K̃2 ≡ K2 +C2 ΥC2. Elimination of the primal variables in (2.8) results in the coarse grid problem [ B1K −1 1 B T 1 +B2K̃ −1 2 B T 2 B2K̃ −1 2 C T 2 Υ ΥC2K̃ −1 2 B T 2 ΥC2K̃ −1 2 C T 2 Υ−Υ ] [ λ μ ] = [ d1 d1 ] ...

The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate ...

OBJECTIVE There is a global call for formulations, which are better suited for children of different age categories and in a variety of settings. One key public health area of interest is age-appropriate paediatric antibiotics. We aimed to identify clinically relevant paediatric formulations of antibiotics listed on pertinent formularies that were not on the WHO Essential Medicines List for Chi...

Hand cream is used for rehydrating and improving skin properties. The skin is the first point of contact with the environment. Thus having healthy skin with proper barrier properties is quite important. The beneficial effects of fish oil on skin make it a favorable ingredient to be used in hand care products. In the present study, the efficacy and stability of various hand cream formulations us...

Hand cream is used for rehydrating and improving skin properties. The skin is the first point of contact with the environment. Thus having healthy skin with proper barrier properties is quite important. The beneficial effects of fish oil on skin make it a favorable ingredient to be used in hand care products. In the present study, the efficacy and stability of various hand cream formulations us...

the hydroalcoholic extracts of dried ligulate florets of calendula officinalis l., dried leaves of plantago major l., and dried aerial parts of vinca major l. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate was ...