an oral sustained-release floating tablet formulation of metformin hcl was designed and developed. effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc-peo polymer combination, respectively. tablet composition was optimized by response surface methodology (rsm). seventeen (17) trial formulations were analyzed according to box-behnken desi...

objective(s): this study evaluates the effect of substitution of microcrystalline cellulose (mcc) with ethylcellulose (ec) on mechanical and release characteristics of theophylline pellets. materials and methods: the effect of addition of ec was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. also the effect of type of granulating liqui...

In this study, new antimicrobial hydrogels were prepared via reaction of functionalized-tragacanthgum (TG) biopolymer by quaternary ammonium functionalization of TG (QTG) with acrylic acid(AA). Characterization of the QTG hydrogels (QTG-AA) was carried out by FTIR,thermogravimetric analysis (TGA), and 1H NMR. Dynamic mechanical analysis, (DMA) wasconducted to characteriz...

frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. in the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...

Vitamin E (α-tocopherol) is a natural antioxidant very useful for preventing the harmful effects of UV sun rays as skin aging and cancers. In this study, different MLV formulations were made using egg lecithin and varying molar ratios of α-tocopherol and/or cholesterol, and their encapsulation efficiencies were determined. The best liposomal product was incorporated into a carbomer 980 gel. The...

The spectrum profile that emerges in molecular spectroscopy and atmospheric radiative transfer as the combined effect of Doppler and pressure broadenings is known as the Voigt profile function. Because of its convolution integral representation, the Voigt profile can be interpreted as the probability density function of the sum of two independent random variables with Gaussian density (due to t...

The spectrum profile that emerges in molecular spectroscopy and atmospheric radiative transfer as the combined effect of Doppler and pressure broadenings is known as the Voigt profile function. Because of its convolution integral representation, the Voigt profile can be interpreted as the probability density function of the sum of two independent random variables with Gaussian density (due to t...

Objective(s): The purpose of this study was preparation and evaluation of PVA-Fe3O4 nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values. Methods: Fe3O4 nanoparticles were synthesized by coprecipitation...

The aim of this study was to prepare dry powder inhalers (DPIs) containing amphotericin B-loaded solid lipid nanoparticles (AMB-SLNs) as an alternative approach for prevention of pulmonary aspergillosis. For solubilizing AMB in small amounts of organic solvents ion paired complexes were firstly formed by establishing electrostatic interaction between AMB and distearoyl phosphatidylglycerol (DSP...