BACKGROUND To assess the reliability and accuracy of the Framingham coronary heart disease (CHD) risk function adapted by the Registre Gironí del Cor (REGICOR) investigators in Spain. METHODS A 5-year follow-up study was completed in 5732 participants aged 35-74 years. The adaptation consisted of using in the function the average population risk factor prevalence and the cumulative incidence ...

BACKGROUND This study aimed to validate the Korean Genome Epidemiology Study (KoGES) risk score to predict the 4-year risk of hypertension (HT) in a large nationwide sample, and compare its discrimination and calibration with the Framingham and blood pressure (BP)-only models. METHODSANDRESULTS This study analyzed 69,918 subjects without HT at baseline from the National Sample Cohort in the N...

INTRODUCTION This study was done in order to evaluate the effect of serum levels of total cholesterol, triglycerides, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol on 10-year coronary heart disease risk distribution change. MATERIAL AND METHODS This study included 110 subjects of both genders (71 female and 39 male), aged 29 to 73, treated at the Outpatient Depa...

BACKGROUND To evaluate the U.K. Prospective Diabetes Study (UKPDS) and Framingham risk equations for predicting short-term risk of coronary heart disease (CHD) events among adults with long-standing type 2 diabetes, including those with and without preexisting CHD. METHODS Prospective cohort of U.S. managed care enrollees aged ≥ 18 years and mean diabetes duration of more than 10 years, parti...

BACKGROUND Several studies have shown associations between hyperglycemia and risk of cardiovascular disease (CVD) and mortality, yet glucose-lowering treatment does little to mitigate this risk. We examined whether associations between hyperglycemia and CVD risk were explained by underlying insulin resistance. METHODS In 60 middle-aged individuals without diabetes we studied the associations ...

BACKGROUND AND PURPOSE Emerging evidence raises the possibility of an association between depression and stroke risk. This study sought to examine whether depressive symptoms are associated with an increased risk of cerebrovascular events in a community-based sample. METHODS A prospective study was conducted on 4120 Framingham Heart Study participants aged 29 to 100 years with up to 8 years o...

Despite the wealth of longitudinal data on the health dynamics of human populations, information on covariates (risk factors) changes in those studies has not been systematically and fully exploited. In this work we use the 46-year follow-up of the Framingham Heart Study to analyze dynamics of these risk factors in survival models that go far beyond the standard linear dynamic formulation. We f...

BACKGROUND Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors. METHODS AND RESULTS We examined the mortality of subjects 55 to 94 years of age who developed AF during 40 years of follow-up of the original Framingham Heart Study cohort. Of the original 5209 subjects,...