INTRODUCTION Decreasing of testosterone level is an important part of a male elderly. MATERIAL AND METHODS To describe this phenomenon a PubMed and national databases were searched for 17β-dehydrotestosterone, common testosterone, free testosterone, 17β-estradiol, luteinizing hormone, partial androgen deficiency of aging men. RESULTS The reduction in intensity of the processes of tissue ren...

The proposed key symptoms of the female androgen insufficiency syndrome (FAIS) include reduced libido, diminished well being and lowered mood. The diagnosis of FAIS is made on the basis of these symptoms in the setting of a low serum free testosterone level. However, there is currently no readily available inexpensive assay which reliably measures free testosterone levels in the female range. T...

Objective Late-onset hypogonadism, or androgen deficiency in the aging male, is a significant cause of morbidity in older men. Many men in the low normal or equivocal range for low testosterone level exhibit signs and symptoms of hypogonadism. Serum testosterone is an imperfect maker for hypogonadism as symptoms vary greatly within the low to low normal range in addition to variations among tes...

BACKGROUND Saliva reflects the plasma free fraction of testosterone which is biologically active, and available for uptake by tissues. Testosterone concentration in saliva, though differing slightly from the concentration of unbound testosterone in serum, is in good correlation with the latter, indicating that salivary testosterone provides a reliable method for determination of serum free test...

OBJECTIVE To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges. DESIGN Pilot study. SETTING University-based hospital. PATIENT(S) Ten bilaterally oophorectomized women. INTERVENTION(S) Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg). MAIN OUTCOME MEASURE(S) Total testosterone, andros...

BACKGROUND The aim of this study was to assess the effects chronic kidney disease (CKD) had on sex hormones and lipids in a subgroup of men between 18 and 50 years old with CKD 1-5 stage without diabetes and not treated with hemodialysis. METHODS Data were collected from 101 men with different CKD stages. RESULTS Higher CKD stage (lower function) had a significant negative linear trend on t...

In young men, chronic ingestion of 100 mg androstenedione (ASD), three times per day, does not increase serum total testosterone but does increase serum estrogen and ASD concentrations. We investigated the effects of ASD ingestion in healthy 30- to 56-yr-old men. In a double-blind, randomly assigned manner, subjects consumed 100 mg ASD three times daily (n = 28), or placebo (n = 27) for 28 days...

OBJECTIVE To investigate the andropause phenomenon in Iraqi healthy subjects by evaluating serum free testosterone (FT) concentrations in association with age. METHODS This study was carried out at the Biochemistry Department, College of Medicine, University of Baghdad, between February 2012 and October 2012. This cross sectional control subject's study included 251 healthy Iraqi men with an ...

OBJECTIVE To investigate the effects of mesterolone on prostate in patients treated for aging male syndrome. METHODS The cross-sectional study was conducted from June to September, 2009, at endocrinology and metabolism department of Yuzuncu Yil University, Van, Turkey, andcomprised patients with symptoms of aging male syndrome and/or low testosterone. They were given mesterolone 50 mg/day per...

Background. The low serum level of testosterone in the elderly subjects may contribute to coronary artery disease (CAD). Our aim is to study serum levels of free testosterone in elderly men with CAD. Subjects and Methods. This study was conducted on 100 elderly males with CAD, one half of them was presented with ACS (with mean age 69.6 ± 2.44 year), and the other half was presented with stable ...