Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated.   Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...

we have previously shown the adjuvant activity of propranolol (prp) (a beta-adrenergic receptor antagonist) using a vaccine model for salmonella typhimurium. in this study prp was used as an adjuvant in combination with plasmodium  berghei  (p. berghei)  whole blood stage (pwbs) antigens. balb/c mice were immunized three times with a 2-week interval, either pwbs vaccine alone or in combination ...

background and objectives rheumatoid arthritis (ra) is a chronic inflammatory disease which is characterized by joint swelling, and synovial inflammation. c reactive protein (crp) and ceruloplasmin (cp) are identified as important biomarkers of ra and various inflammatory diseases. curcumin, a widely used yellow color spice is the most active component of curcuma longa l (turmeric). curcumin co...

background: adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. despite immunostimulatory properties, the use of bacterial lipopolysaccharide (lps) as an adjuvant has been hampered due to its toxicity and pyrogenicity. brucella abortus lps is less toxic and has no pyrogenic properties compared to lps from other gram negat...

background and objectives : haemorrhagic septicaemia (hs), caused by pasteurella multocida, is the most important bacterial disease of cattle and buffaloes in india. oil adjuvant vaccine (oav) is the most potent vaccine available for the control of hs. the study aims to evaluate the effect of alum co-adjuvantation of oav on emulsion stability and immune response. materials and methods : two dif...

background: recent researches have led to find strategies to prevent relapse and to improve survival for gastric cancer patients, including preoperative neo-adjuvant approaches. however, the efficacy of some neo-adjuvant regimens including 5-fluorouracil, cisplatin, and docetaxel have been less investigated. the present study evaluated the outcome and mid-term survival of patients with gastric ...

Foot-and-mouth disease is an important viral disease of cloven-hoofed animals. Inactivated whole particle virus vaccines are still widely used in prophylactic vaccination campaigns. The choice of adjuvant is a very important factor in enhancing immune responses and the efficacy of inactivated vaccines. Montanide ISA 61 VG is a new ready-to-use mineral oil-based adjuvant developed by SEPPIC Inc....

  Background and Objective: Esophageal cancer especially squamous cell carcinoma (SCC) is one of the most common gastro intestinal malignancies in north part of Iran (Khorasan). The standard treatment for esophageal cancer is surgical resection, but its outcome remains poor. Then, the oncologists try to treat this cancer with sandwich protocols especially neo-adjuvant chemo-radiotherapy. Sever...