PURPOSE The aim of this study was to determine the progressive processes of polymorphic transformation of different gabapentin (GBP) polymorphs by using hot-stage Fourier transform infrared (FTIR) microspectroscopy. METHODS Four polymorphs of GBP were previously prepared and then identified by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, FTIR microspectroscopy and...

Fourier transform infrared (FTIR) microspectroscopy has been applied to a study of prostate cancer cell lines derived from different metastatic sites and to tissue from benign prostate and Gleason-graded malignant prostate tissue. Paraffin-embedded tissue samples were analysed by FTIR, after mounting onto a BaF(2) plate and subsequent removal of wax using Citroclear followed by acetone. Cell li...

This article reviews some of the recent advances on FTIR spectroscopy in areas related to natural tissues and cell biology. It is the second review publication resulting from a detailed study on the applications of spectroscopic methods in biological studies and summarizes some of the most widely used peak frequencies and their assignments. The aim of these studies is to prepare a database of m...

Bacterial pathogens are known for their wide range of strategies to specifically adapt to host environments and infection sites. An in-depth understanding of these adaptation mechanisms is crucial for the development of effective therapeutics and new prevention measures. In this study, we assessed the suitability of Fourier Transform Infrared (FTIR) spectroscopy for monitoring metabolic adaptat...

SF6 total columns are successfully retrieved from FTIR measurements (Saint Denis and Maïdo) at Réunion Island (21◦S, 55◦E) between 2004-2016 using the SFIT4 algorithm: the retrieval strategy and the error budget are presented. The FTIR SF6 retrieval has independent information in only one individual layer, covering the whole troposphere and the lower stratosphere. The trend of SF6 is analysed b...

the present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (pvp) and ethyl cellulose (ec) using a d-optimal mixture design. the prepared transdermal patches were subjected to different physicochemical evaluation. the surface topography of the patches was examined by scanning electron microscopy (s...

based on the accumulated data, ftir spectroscopy seems to be a highly sensitive tool in cervical cancer diagnosis. we, therefore, employed this technique in a screening type of research here in tehran. the purpose of this study was to look for the spectral pattern differences between normal and malignant cervix samples in iranian women. through formal and informal announcements, all gynecology ...

Advance protein based nanobiotechnology are now, known for its advanced approach to synthesize various nanomaterials using various newly developed chemical and green technologies to carry out their applications in various fields of life sciences. Now these days, Bovine serum albumin nanoparticles (BSA NPs) are very popular as non vehicle systems for drug delivery used in number of therapeutic s...

The N-terminal domain of HIV-1 glycoprotein 41,000 (gp41) participates in viral fusion processes. Here, we use physical and computational methodologies to examine the secondary structure of a peptide based on the N terminus (FP; residues 1–23) in aqueous and detergent environments. C-Fourier transform infrared (FTIR) spectroscopy indicated greater -helix for FP in lipid-detergent sodium dodecyl...

BACKGROUND The routine diagnosis of Streptococcus spp. and other mastitis associated gram-positive, catalase-negative cocci is still based upon biochemical tests and serological methods, which frequently provide ambiguous identification results. We therefore aimed to establish an accurate identification system for differential diagnosis of mastitis associated Streptococcus spp. and related spec...