OBJECTIVE To determine the effects of topical administration of 20% oltipraz solution on histomorphometrical and stereological aspects of skin tissue in full thickness skin wounds in laboratory rats. METHODS Thirty-six male Wistar portion rats (220±20 g) were randomly divided into three groups (n=12). On the first day of experimentation, a 1-cm2 circular wound was made on the posterior surfac...

ReGeneraTing Agents (RGTAs), a family of polymers engineered to protect and stabilize heparin-binding growth factors, have been shown to promote tissue repair and regeneration. In this study, the effects of one of these polymers, RGTA OTR4120, on healing of full-thickness excisional wounds in rats were investigated. Two 1.5 cm diameter circular full-thickness excisional wounds were created on t...

OBJECTIVE To accelerate wound healing through promoting vascularization by using reactive oxygen species (ROS)-responsive nanoparticles loaded with stromal cell-derived factor-1α(SDF-1α). METHODS The ROS-reactive nanomaterial poly-(1,4-phenyleneacetone dimethylene thioketal) was synthesized, and its physical and chemical properties were characterized. ROS-responsive nanoparticles containing S...

Suday, Sptem er 5, 2016 pre-vascularized full thickness skin flap, which recapitulates the inherent hierarchical vasculature found within the human skin and is suitable to provide whole tissue perfusion. We provide the platform for an on-demand, geometrically tunable tissue engineered skin equivalent with an anastomosable vascular network which will transform reconstructive surgical practice by...

Suday, Sptem er 5, 2016 pre-vascularized full thickness skin flap, which recapitulates the inherent hierarchical vasculature found within the human skin and is suitable to provide whole tissue perfusion. We provide the platform for an on-demand, geometrically tunable tissue engineered skin equivalent with an anastomosable vascular network which will transform reconstructive surgical practice by...

background: the effect of several probiotics on diseases of the gastrointestinal tract, including gastric ulcers is well reported. however, there are limited numbers of studies assessing the impact of bacillus subtilis (b. subtilis) probiotic on skin wound healing. m aterials and methods: fifty male rats were assigned to 3 different groups randomly. a 1.5 cm longitudinal full thickness incision...

BACKGROUND For the noncolonized wound, achieving tension-free, primary wound closure is ideal. Some surgeons advocate imbrication of deeper tissues rather than undermining, posing that imbrication preserves more dermal perfusion while still reducing tension at the wound edge. We sought to determine which technique most reliably reduced wound tension while preserving dermal wound perfusion. ME...

Major degloving injuries of the lower limb are daunting lesions because they are relatively rare and always produce larger soft tissue defects than direct visual inspection that could be predicted in the emergency room. Enough body of the medical literature supports the excision of the avulsed tissue and replaces it as a full-thickness skin graft. However, almost paradoxically, there is little ...