UNLABELLED It is widely recognized that radiopharmaceuticals are generally distributed nonuniformly in tissues. Such nonuniformities are observed over the entire range of spatial levels, ranging from organ to subcellular levels. The implications of nonuniform distributions of radioactivity for dosimetry, and ultimately for the biologic response of tissues containing radioactivity, have been inv...

Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency. To study this response in the absence of changes ...

SDZ-ADL is a biosimilar of reference adalimumab. Here, the safety and effectiveness data from British Association Dermatologists Biologic Immuno-modulators Register (BADBIR) are reported. In set, were compared with conventional systemics data. quality-of-life patients treated as first-time biologic, or who switched previous biologic to SDZ-ADL, assessed using Psoriasis Activity Severity Index (...

Biologics have greatly improved the management of rheumatoid arthritis (RA), demonstrating efficacy and safety in alleviating symptoms, inhibiting bone erosion, and preventing loss of function. Unmet therapeutic needs in RA remain; however, further advances require an understanding of issues left unaddressed under the current treatment paradigm. Most biologic-naïve and biologic-pretreated patie...

Rheumatoid arthritis (RA) is a prevalent systemic disease that causes significant joint dysfunction and disability. Dramatic improvements in the management of RA have been achieved with the use of biologic therapies aimed at cytokines, and B and T lymphocytes. Abatacept, a soluble receptor-IgG fusion protein that interferes with T-cell co-stimulation, has now been shown to improve symptoms, sig...

951 As shown in a previous photoessay, beautiful images of plants and other biologic systems can be obtained in total darkness.1 In a deep sense, underlying metabolic processes cause them to “glow in the dark.” This low-level biologic chemiluminescence is commonly known as biophoton emission. State-of-the-art low-light charge-coupled device cameras originally developed for applications in astro...

While genetic alteration in the p85α-p110α (PI3K) complex represents one of the most frequent driver mutations in cancer, the wild-type complex is also required for driving cancer progression through mutations in related pathways. Understanding the mechanistic basis of the function of the phosphoinositide 3-kinase (PI3K) is essential for designing optimal therapeutic targeting strategies. Recen...