The outer hair cell (OHC) from the organ of Corti plays a crucial role in hearing through its unique voltage-dependent mechanical responses. Furosemide, one of the loop diuretics, disrupts normal cochlear function. Here we report on direct effects of furosemide on OHC motility-related, voltage-dependent capacitance using the whole-cell patch-clamp technique. Extracellularly applied furosemide r...

Background Blood Oxygen Level Dependent (BOLD) magnetic resonance (MR) is a novel imaging tool that is able to detect tissue oxygenation and has recently been utilized to evaluate renal function in patients with renal artery stenosis (RAS). Renal BOLD imaging is typically performed before and after a furosemide stimulus to assess kidney viability. Furosemide blocks the sodium-potassium2chloride...

BURG, MI., L. STONER, J. CARDINAL, AND N. GREEN. Furosemide effect on isolated perfused tubules. Am. J. Physiol. 225(l): 119-124. 1973 .-Proximal convoluted tubules, thick ascending limbs of Henle’s loop, and cortical collecting tubules were dissected from rabbit kidneys, and perfused in vitro. The effect of the diuretic agent furosemide on electrolyte transport and electrical potential differe...

The objective of this study was to evaluate the pharmacokinetic and pharmacodynamic properties of furosemide following gastroretentive dosage from (GRDF) administration. A furosemide (60 mg) GRDF, releasing the drug during 6 hours in vitro, or an immediate-release tablet was administered to healthy male volunteers (N = 14) in a crossover design. Food and liquid intake were standardized; urine w...

Afferent (Af-Art) and efferent arterioles resistance regulate glomerular capillary pressure. The nephron regulates Af-Art resistance via: 1) vasoconstrictor tubuloglomerular feedback (TGF), initiated in the macula densa via Na-K-2Cl cotransporters (NKCC2) and 2) vasodilator connecting tubuloglomerular feedback (CTGF), initiated in connecting tubules via epithelial Na channels (ENaC). Furosemide...

PURPOSE Diuretics are the primary treatment for the management of chronic heart failure (HF) symptoms and for the improvement of acute HF symptoms. The rate of delivery to the site of action has been suggested to affect diuretic pharmacodynamics. The main objective of this clinical trial was to explore whether a prolonged release tablet formulation of torasemide (torasemide-PR) was more natriur...

OBJECTIVES We sought to determine the effect of aspirin on the venodilator effect of furosemide in patients with chronic heart failure (CHF) BACKGROUND: Furosemide has an acute venodilator effect preceding its diuretic action, which is blocked by nonsteroidal anti-inflammatory, drugs. The ability of therapeutic doses of aspirin to block this effect of furosemide in patients with CHF has not bee...

The relations among the renin-angiotensin-aldosterone system, renal prostaglandin E, the renal kallikrein-kinin system, and furosemide diuresis were studied in 16 healthy volunteers. The diuretic and natriuretic effects of furosemide were accompanied by an increase in the excretion rates of urinary prostaglandin E (UPCEV), urinary kallikrein (UkaiiV), and urinary kinin (UkininV), and in plasma ...

Pedersen M, Vajda Z, Stødkilde-Jørgensen H, Nielsen S, Frøkiær J. Furosemide increases water content in renal tissue. Am J Physiol Renal Physiol 292: F1645–F1651, 2007. First published January 30, 2007; doi:10.1152/ajprenal.00060.2006.—The present study was designed to evaluate the short-term effects of intravenous administration of furosemide on key functions in the kidney cortex and the outer...

Rowland, Neil E., and Kenneth R. Morian. Roles of aldosterone and angiotensin in maturation of sodium appetite in furosemide-treated rats. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1453–R1460, 1999.— When rats are treated with furosemide, there is a rapid natriuresis. However, increased sodium appetite does not occur until some time later. One hypothesis to explain this d...