Hemophilia A (HA) is an X-linked genetic hemorrhagic disorder resulting from a deficiency of blood coagulation factor VIII. The mutation type within the factor VIII gene may influence the clinical severity of hemophilia. It has also recently been suggested that the clinical phenotype of HA is influenced by co-inheritance of the factor V G1691A mutation or the factor II G20210A variant. This cli...

Pregnancy is a hypercoagulable state secondary to an increase in coagulation factors, reduction naturally occurring anticoagulants, and impairment of fibrinolysis. losses were divided into preclinical, first trimester clinical, second trimester. A meaningfully increased rate preclinical pregnancy failure Leiden mutation carriers was found than no activated protein C deficiency patients. Another...

We have investigated the prevalence of the Factor II G20210A and Factor V G1691A single nucleotide polymorphisms (SNPs) in a South Indian-Tamil Nadu population. The SNP genotyping was performed using a polymerase chain reaction (PCR)/restriction fragment length polymorphism analysis and by a recently FDA-approved LightCycler real-time PCR assay. Of 72 samples that were genotyped, 4 (5.5%) patie...

Background Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to investigate the prevalence and clinical impact of factor V Leiden G1691A (FVL) and prothrombin G20210A mutations among Palestinian sickle cell disease (SCD) patients. Methods A total of 117 SCD patients, including 59 patients with sickle cell anemia (SS), 33 patients with...

Thromboembolism is a clinical finding that occurs due to thrombus; formed in the vascular system and has various etiological factors. It can be classified as central peripheral thromboembolism. Our objective this study explore genetic risk factors thromboembolism reveal differences. 342 patients were retrospectively included between January 2016 December 2019. Demographic characteristics, for m...

OBJECTIVE Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins). The aim of this study was to determine the prevalence and characteristics of inherited thrombophilia in Egyptian Budd-Chiari syndrome patients. METHODS The study included 47 Budd-Chiari syndrome ...