Alzheimer disease (AD) diderita oleh 30-35 juta penderita di dunia dan diperkirakan akan meningkat hingga 400% dalam 30 tahun kedepan Indonesia. Salah satu obat yang telah diterima untuk pengobatan AD diisolasi dari tanaman Galanthus nivalis berperan sebagai inhibitor acetylcholinesterase (AChe), galantamine, memiliki efek singkat. Penerimaan terhadap senyawa herbal semakin luas karena kebutuha...

Abstract Plants have long served as a first line of defence against viral-borne diseases. Their chemical constituents also afforded sound basis for antiviral drug discovery. The plant family Amaryllidaceae is distinguished its isoquinoline alkaloids, some which proved to be interesting leads. Its lectin (or agglutinin) principles likewise attracted considerable attention potential drugs. This r...

DIAGNOSIS. Leptonycteris yerbabuenae (Fig. 1) is 1 of 4 North American bats with a nose leaf. L. yerbabuenae can be distinguished from Choeronycteris mexicana and Macrotus californicus by the absence of a conspicuous tail and presence of brownish pelage in L. yerbabuenae (Arita 1999). Pelage of L. yerbabuenae is shorter and denser in comparison to the longer and fluffier pelage of L. nivalis (D...

Abstract Background Curculigo latifolia is a perennial plant endogenous to Southeast Asia whose fruits contain the taste-modifying protein neoculin, which binds sweet receptors and makes sour taste sweet. Although similar snowdrop ( Galanthus nivalis ) agglutinin (GNA), contains mannose-binding sites in its sequence 3D structure, neoculin lacks such has no lectin activity. Whether of C. other p...

Cemeteries not only serve as burial sites but also a habitat for many animal and plant species, the specific management of cemeteries creates conditions that hardly exist anywhere else. So-called stinzen plants are those species show connection to old garden cultures need precisely these conditions. Many early-flowering geophytes. We examined which factors influence distribution abundance (=cov...

The virus-encoded envelope proteins of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) typically contain 26 to 30 sites for N-linked carbohydrate attachment. N-linked carbohydrate can be of three major types: high mannose, complex, or hybrid. The lectin proteins from Galanthus nivalis (GNA) and Hippeastrum hybrid (HHA), which specifically bind high-mannose carbohydrat...

Exposure of HIV-1 to dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-expressing B-lymphoblast Raji cells (Raji/DC-SIGN) but not to wild-type Raji/0 cells results in the capture of HIV-1 particles to the cells as measured by the quantification of cell-associated p24 antigen. Cocultivation of HIV-1-captured Raji/DC-SIGN cells with uninfected CD4+ T lymphoc...