Pregnancies achieved from oocyte, sperm or embryo donation are unique, since they have resulted from donor gametes that are immunologically foreign to the mother. Thus, studying the obstetric outcome of such pregnancies may shed some light on the pathophysiology of preeclampsia, particularly in women conceiving with donated embryos, since the entire fetal genome is allogenic in these pregnancie...

Genetic studies have identified a family of receptor-like kinases (RLKs) involved in the control of reproduction in the model plant Arabidopsis. Each RLK-dependent signaling pathway is active in cells associated with either male or female gametes. Collectively, these RLKs control the delivery of sperm cells to female gametes.

Infertile couples including cancer survivors stand to benefit from gametes differentiated from embryonic or induced pluripotent stem (ES/iPS) cells. It remains challenging to convert human ES/iPS cells into primordial germ-like cells (PGCLCs) en route to obtaining gametes. Considerable success was achieved in 2016 to obtain fertile offspring starting with mouse ES/iPS cells, however the specifi...

rapid development in assisted reproductive techniques along with relieving the pain of childlessness has brought new ethical and policy dilemmas. posthumous assisted reproduction is the most challenging, difficult and sensitive issue to be discussed ethically and religiously. in this paper the acceptability of the posthumous reproduction in islamic contexts is evaluated and major concerns like ...

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The assembly and maintenance of eucaryotic flagella and cilia depend on the microtubule motor, kinesin-II. This plus end-directed motor carries intraflagellar transport particles from the base to the tip of the organelle, where structural components of the axoneme are assembled. Here we test the idea that kinesin-II also is essential for signal transduction. When mating-type plus (mt+) and mati...

Kirstin Mac Dougall, M.F.A., Gay Becker, Ph.D., Joanna E. Scheib, Ph.D., and Robert D. Nachtigall, M.D. a Institute for Health and Aging, University of California, San Francisco, San Francisco, California, b Department of Psychology, University of California, Davis, Davis, California, and c Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, ...