نتایج جستجو برای: gasotransmitters
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In contrast to most vertebrates, freshwater turtles of the genera Trachemys and Chrysemys survive total oxygen deprivation for long periods time. This remarkable tolerance makes them ideal August Krogh's model animals study adaptions deprivation. The gasotransmitters nitric oxide (NO) hydrogen sulfide (H 2 S) their metabolic derivatives are central in regulating physiological responses Here, we...
The authors van den Born et al. (1) have written a timely Perspective in this issue of Diabetes. Both type 1 and type 2 diabetes have reached epidemic proportions throughout the world, afflicting over 400 million people. Moreover, the number of individuals that will develop diabetes is predicted to rise (2). Both individuals with type 1 and type 2 diabetes are at a significantly greater risk fo...
Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an unidentified mechanism. Here we propose that HNO is generated as a result of the reaction of the ...
Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases
Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous intercellular messenger involved in the modulation of several processes, such as blood flow and platelet aggregation control, essential to maintain vascular homeostasis. NO is produced by nitric oxide synthases (NOS) and its effects are mediated by cGMP-dependent or cGMP-independent mechanisms. Growing e...
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