BACKGROUND Although patients may present with typical chest pain and exhibit ischemic changes on the cardiac stress test, they are frequently found to have a normal coronary angiogram. Thus, we wanted to determine which procedures should be performed in order to make an adequate diagnosis of the cause of chest pain. METHODS 121 patients (males: 42, 34.7%) who had a normal coronary angiogram w...

Idiopathic pulmonary fibrosis (IPF) is a dreaded disease of uncertain etiology and no available cure. It is still unclear if a causal relationship exists between gastro-esophageal reflux (GER) and IPF, but studies have shown an increased prevalence of acid reflux in patients with IPF. We describe a patient with achalasia and GER who went on to develop IPF. She underwent a rapidly worsening cour...

Systemic sclerosis is a rare connective tissue disease, distinctive features of which are fibrosis and microangiopathy. The esophagus is one of the most commonly involved internal organs. Most patients experience dysphagia, difficulties in swallowing and gastro-esophageal reflux. However, in up to one third of cases, the initial onset of esophageal disease may be clinically silent. There are se...

A MODIFIED NISSEN TOUPET PROCEDURE FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE AND HIATAL HERNIA: HOW I DO IT (Abstract): The laparoscopic fundoplication became the standard treatment for gastro-esophageal reflux disease and hiatal hernia. Nissen and Toupet techniques are the most used surgical procedures. Which of these techniques is superior is a subject of debate. The Nissen procedu...

____________________________________________________________________________________________________________ Introduction Gastro-esophageal reflux disease (GERD) is said to affect 4 to 7 percent of the US population and is on the rise. Over the past 3 decades, the prevalence of GERD has increased two-fold, and some sources estimate prevalence between 10 to 20 percent.1, 2 It is characterized by...

background epidemiology of diseases changes over time with changes in socio-economic status, culture and health care systems. gastroesophageal reflux disease (gerd) and peptic ulcer disease (pud) are among the diseases whose epidemiology has changed over the past few decades in the west. studies addressing the trend of gerd and pud occurrence in iran are lacking. we aimed to look at the time tr...

e-Table 1. Comparison of pulmonary function test results between Af-IgE-sensitized and non-IgEsensitized patients. Results are represented as mean ± SD, except for Raw %pred, where median (IQR) is used. p-values for multivariate analysis with age, gender, BMI, P. aeruginosa colonization, pancreatic insufficiency and gastro-esophageal reflux disease as covariates are given. n = number of patient...

BACKGROUND None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. METHODS Two hundred and fifty patients with symptoms suggestive of GERD and 35 asym...

Gastro-esophageal reflux disease (GERD) is the result of the acid contents regurgitation back from the stomach into the esophagus. According to the endoscopic findings, GERD can be divided into two main forms: non-erosive (NERD) and erosive reflux esophagitis. The pathogenesis of GERD is associated with the impaired function of the antireflux barrier. Disturbances of the autonomic nervous syste...

Non-erosive reflux disease (NERD) and functional heartburn (FH) are two different clinical entities and the clear distinction between the two forms is actually possible thanks to the use of impedance-pH monitoring. NERD is the more common manifestation of gastro-esophageal reflux disease (GERD), one of the most widespread chronic gastrointestinal disorders in Western countries. The absence of v...