Using population-based and epidemiologic data for 25 countries in Asia (22 GAVI-Alliance eligible countries, Thailand, China and Japan), a model-based approach was used to estimate averted cervical cancer cases and deaths, disability-adjusted life years (DALYs) and incremental cost-effectiveness ratios (I$/DALY averted) for vaccination of young adolescent girls against human papillomavirus (HPV...

Adoption of new vaccines in developing countries is critical to reducing child mortality and meeting Millennium Development Goal 4. However, such introduction has historically suffered from significant delays that can be attributed to various factors including (i) lack of recognition of the value of a vaccine, (ii) factors related to weak health systems, and (iii) policy considerations. Recentl...

INTRODUCTION We examined the cost-effectiveness of a rotavirus immunization program in Kyrgyzstan, a country eligible for vaccine funding from the GAVI Alliance. METHODS We estimated the burden of rotavirus disease and its economic consequences by using national and international data. A cost-effectiveness analysis was conducted from government and societal perspectives, along with a range of...

Supplement I t is well known that Streptococcus pneumoniae remains a leading cause of childhood mortality; in 2008, it was estimated to be responsible for over 500,000 deaths in children aged 1–59 months. 1 It is also known that the pneumococcus is a cause of significant morbidity and mortality among those younger and older than the 1-to 59-month age group, 2,3 although prevention of disease in...

Rotavirus vaccines are being introduced in several low- and middle-income countries across the world with and without support from the GAVI Alliance. India has the highest disease burden of rotavirus based on morbidity and mortality estimates and several indigenous vaccine manufacturers are developing rotavirus vaccines. One candidate has undergone phase III testing and others have completed ev...

Submit Manuscript | http://medcraveonline.com Abbreviations: BCG: Bacille Calmette-Guerin Vaccine; CI: Confidence Interval; CD4, CD8: A Type of White Blood Cell Help to Defend the Body from Infections; DNA: Deoxyribonucleic Acid; EPI: Expanded Program on Immunizations; GAVI: Global Alliance for Vaccines and Immunization; HIV: Human Immunodeficiency Virus; IAVI: International AIDS Vaccine Initia...