This paper presents a design and implementation of a whole-program interprocedural optimizer built in the GCC framework. Through the introduction of a new language-independent intermediate representation, we extend the current GCC architecture to include a powerful mid-level optimizer and add link-time interprocedural analysis and optimization capabilities. This intermediate representation is a...

BACKGROUND Originating from Primordial Germ Cells/gonocytes and developing via a precursor lesion called Carcinoma In Situ (CIS), Germ Cell Cancers (GCC) are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS). During physiological germ cell formation/maturation, epigenetic processes guard homeostasis by regulating the accessibility of the DNA to facilitate tr...

This paper presents a practical prototyping tool for SSA transformations based on PROLOG, and a case study of its applicability using the New Framework for Loop Nest Optimization of the GNU Compiler Collection (GCC). Using this approach, we implemented an induction variable analysis in GCC and performed several experiments for assessing different issues: performance of the generated code, effec...

Purpose. To detect the effects of intravitreal ranibizumab injections on GCC in patients with wet AMD. Methods. 32 wet AMD eyes were selected and submitted at three ranibizumab injections. RTVue-OCT GCC and MM5 protocol were performed before treatment and twenty days after each injection. Results. At baseline mean GCC thickness was 93.9 ± 18.5 μm. Twenty days after each intravitreal injection i...

GNU Compiler Collection (GCC) needs a strategy to support future multicore architectures, which will probably include heterogeneous accelerator-like designs with explicit management of scratchpad memories. Some have further restrictions; for example, SIMD has limited synchronization capabilities. Some platforms will probably offer hardware support for streaming, transactions, and speculation. T...

We read the presented case of retained invasive placenta mimicked gestational choriocarcinoma (GCC)with an enthusiasm [1]. We thought if this is a case of GCC, which sign should be the leading sign. The clinical diagnosis ofGCC is challenging inmost of the cases. The predominant symptom is abnormal vaginal bleeding. Serum human chorionic gonadotropin beta (β-hCG) measurement and doppler ultraso...

Antagonism between the defense hormones salicylic acid (SA) and jasmonic acid (JA) plays a central role in the modulation of the plant immune signaling network, but the molecular mechanisms underlying this phenomenon are largely unknown. Here, we demonstrate that suppression of the JA pathway by SA functions downstream of the E3 ubiquitin-ligase Skip-Cullin-F-box complex SCF(COI1), which target...

This is the first of seven papers resulting from a Society of Environmental Toxicology and Chemistry (SETAC) international workshop titled "The Influence of Global Climate Change on the Scientific Foundations and Applications of Environmental Toxicology and Chemistry." The workshop involved 36 scientists from 11 countries and was designed to answer the following question: How will global climat...

A set of carefully selected compiler optimization options could provide an additional performance boost over the current best default optimization options in the GNU Compiler Collection (GCC) C compiler. However, there are more than 60 optimization options in GCC compiler, which translate to over 260 possible combinations. GCC compiler developers are therefore faced with a challenge. The goal i...

Tumor recurrence and distant metastasis are major causes of treatment failure in gastric cardiac cancer (GCC). Rapid growth of tumor cells and reduced expression of nm23, a metastatic suppressor gene, in tumor cells have been suggested as two important mechanisms for disease progression of GCC. Therefore, to determine the prognostic value of nm23 expression in GCC, we used immunohistochemistry ...