purpose: to quantify the intraobserver reproducibility of retinal nerve fiber layer (rnfl) measurements using scanning laser polarimetry with variable corneal compensation in glaucoma suspect patients. methods: twenty-six eyes of 26 glaucoma suspect patients were included. complete ophthalmologic examination and standard automated perimetry were performed for all of them. rnfl measurements were...

Gonadal steroids profoundly influence several brain functions and are apparently responsible for gender-specific differences in the regulation of hypothalamic-pituitary-adrenal (HPA) secretions. In this study, we examined the so-called "activational" effects of gonadal steroids on the glucocorticoid-mediated regulation of the gene transcription of corticotropin-releasing hormone (CRH) and corti...

PURPOSE To define the clinical characteristics of atypical birefringence images and to describe a quantitative method for their identification. DESIGN Prospective, comparative, clinical observational study. METHODS Normal and glaucomatous eyes underwent complete examination, standard automated perimetry, scanning laser polarimetry with variable corneal compensation (GDx-VCC), and optical co...

BACKGROUND The aim of our study was to assess the role of laser polarimetry and visual evoked potentials (VEP) as potential biomarkers of disease progression in multiple sclerosis (MS). PARTICIPANTS A total of 41 patients with MS (82 eyes) and 22 age-related healthy volunteers (44 eyes) completed the study. MS patients were divided into two groups, one (ON) with a history of optic neuritis (1...

PURPOSE To compare the diagnostic performance of automated imaging for glaucoma. DESIGN Prospective, direct comparison study. PARTICIPANTS Adults with suspected glaucoma or ocular hypertension referred to hospital eye services in the United Kingdom. METHODS We evaluated 4 automated imaging test algorithms: the Heidelberg Retinal Tomography (HRT; Heidelberg Engineering, Heidelberg, Germany...

PURPOSE To assess the strength of the association between retinal nerve fiber layer (RNFL) thickness and optic disc topography measured with confocal retinal tomography (HRT II; Heidelberg Engineering, Dossenheim, Germany), optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA), and scanning laser polarimetry (GDx with variable corneal compensator, VCC; Carl Zeiss Medit...

A 40-year-old male patient suffered from traumatic optic neuropathy in his right eye. Scanning laser polarimetry was arranged at 2 weeks, 9 weeks, 13 weeks, 24 weeks, and 34 weeks after the trauma. Manual or automated visual field testing was also arranged at 1 week, 5 weeks, 16 weeks, and 28 weeks correspondingly. The data revealed using scanning laser polarimetry (program GDx, version 1.0.05;...

Cell fate decisions are integral to zonation and remodeling of the adrenal cortex. Animal models exhibiting ectopic differentiation of gonadal-like cells in the adrenal cortex can shed light on the molecular mechanisms regulating steroidogenic cell fate. In one such model, prepubertal gonadectomy (GDX) of mice triggers the formation of adrenocortical neoplasms that resemble luteinized ovarian s...

Methods: Complete examination, SAP, shortwavelength automated perimetry (SWAP), frequency doubling technology (FDT), scanning laser polarimetry (GDx-VCC), and optical coherence tomography (OCT) of the peripapillary retinal nerve fiber layer (RNFL), optic disc, and macula were performed. Glaucomatous optic neuropathy was defined as cup-disc asymmetry between fellow eyes of greater than 0.2, rim ...

OBJECTIVE To compare the prevalence of structural and psychophysical abnormalities in normal eyes and eyes with glaucomatous optic neuropathy (GON) and normal standard automated perimetry (SAP). METHODS Complete examination, SAP, short-wavelength automated perimetry (SWAP), frequency doubling technology (FDT), scanning laser polarimetry (GDx-VCC), and optical coherence tomography (OCT) of the...