نتایج جستجو برای: gemistocytic glioblastomas

تعداد نتایج: 2385  

Journal: :Journal of the Neurological Sciences 2019

Journal: :F1000 Medicine Reports 2009

2016

Abstract Although glioblastoma is the most common primary brain tumor, primary intraventricular locations are extremely rare; only 21 cases have been reported to date. A retrospectively acquired database of all intracranial glioblastomas treated in 2 different neurosurgical departments during the last 10 years was queried. Patients with histologically proven intraventricular glioblastomas were ...

Journal: :Nature Reviews Clinical Oncology 2018

Journal: :Radiologia 2016
L A Miquelini M S Pérez Akly J A Funes C H Besada

OBJECTIVE To determine whether there are significant differences in the apparent diffusion coefficient (ADC) between the apparently normal peritumor white matter surrounding glioblastomas and that surrounding brain metastases. MATERIAL AND METHODS We retrospectively reviewed 42 patients with histologically confirmed glioblastomas and 42 patients with a single cerebral metastasis. We measured ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Stephen Yip Jiangyong Miao Daniel P Cahill A John Iafrate Ken Aldape Catherine L Nutt David N Louis

PURPOSE Over the past few years, the alkylating agent temozolomide has become the standard-of-care therapy for patients with glioblastoma, the most common brain tumor. Recently, large-scale cancer genome sequencing efforts have identified a hypermutation phenotype and inactivating MSH6 mismatch repair gene mutations in recurrent, post-temozolomide glioblastomas, particularly those growing more ...

Journal: :The New England journal of medicine 2011
Markus Bredel Denise M Scholtens Ajay K Yadav Angel A Alvarez Jaclyn J Renfrow James P Chandler Irene L Y Yu Maria S Carro Fangping Dai Michael J Tagge Roberto Ferrarese Claudia Bredel Heidi S Phillips Paul J Lukac Pierre A Robe Astrid Weyerbrock Hannes Vogel Steven Dubner Bret Mobley Xiaolin He Adrienne C Scheck Branimir I Sikic Kenneth D Aldape Arnab Chakravarti Griffith R Harsh

BACKGROUND Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding nuclear factor of κ-light polypeptide gene enhancer in B-cells inhibitor-α), an inhibitor of the EGFR-signaling pathway, promotes tumorigenesis in glioblastomas that do not have alterations of EGFR. ...

Journal: :Annals of clinical and laboratory science 2011
Susan R Williams John R Parker Alvin Martin Todd Vitaz Joseph C Parker

We report a plasma cell neoplasm in conjunction with a glioblastoma multiforme (GBM) of the conus medullaris in a 42-year-old man. Glioblastoma is a World Health Organization (WHO) grade IV neoplasm that requires surgical intervention, radiation, and possibly chemotherapy. Astrocytomas of the spinal cord are rare neoplasms, with intramedullary glioblastomas comprising only 1% to 3%. Plasma cell...

2013
Bruno Montcel Laurent Mahieu-Williame Xavier Armoiry David Meyronet Jacques Guyotat

5-ALA-induced protoporphyrin IX (PpIX) fluorescence enables to guiding in intra-operative surgical glioma resection. However at present, it has yet to be shown that this method is able to identify infiltrative component of glioma. In extracted tumor tissues we measured a two-peaked emission in low grade gliomas and in the infiltrative component of glioblastomas due to multiple photochemical sta...

Journal: :Clinical neurosurgery 2005
Maria Salpietro Eric C Holland

Glioma is the most common form of primary brain tumor. Although surgical resection of the tumor may be achieved, recurrence is almost inevitable because of the propensity of gliomas for infiltrative growth far into functionally intact brain tissue. Gliomas are classified into four clinical grades, with glioblastoma multiforme (GBM) being the most aggressive type (World Health Organization [WHO]...

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