Background and objectives: Phlomis olivieri Benth. (Lamiaceae) is a medicinal plant widely distributed in Iran. In the present study, we have investigated the phytochemical constituents, antioxidant activity and general toxicity potential of the aerial parts of this species. Methods: Silica gel (normal and reversed phases) and Sephadex LH-20 colu...

Toxicity has emerged during the clinical development of many but not all nucleotide inhibitors (NI) of hepatitis C virus (HCV). To better understand the mechanism for adverse events, clinically relevant HCV NI were characterized in biochemical and cellular assays, including assays of decreased viability in multiple cell lines and primary cells, interaction with human DNA and RNA polymerases, an...

The number of older patients with breast cancer has increased due to the aging general population. use a geriatric assessment in this population been advocated many studies and guidelines as it can be used identify high risk populations for early mortality toxicity. Additionally, parameters could predict relevant outcome measures. This systematic review summarizes all available evidence on pred...

Toxicity of four types of industrial wastewater, treated by Fenton’s reagent, was analyzed. Toxicity was measured using bioluminescent bacteria Vibrio fischeri NRRL B-11177. Application of Fenton’s reagent was a efficient method for treatment of this wastewater. Nevertheless, high efficiency of organic components degradation was not always followed by reduction of toxicity to a very low level. ...

Eremostachys pulvinaris (family: Labiatae), one of the 60 species of the genus Eremostachys, occurs mainly in central Asian countries, e.g. Iran, Armenia, Ashgabad and the USSR. The rhizomes of this plant were collected from Tabriz in Azarbaijan province during September-October 2003. There is no report on any previous phytochemical investigation on E. pulvinaris available todate, phytochemical...

The pace of technological advancement in today’s society has generated an enormous demand for methods facilitating the intelligent testing for the toxicity of new chemicals. Until now it is common use to make prediction based on ‘real’ tests. Recent investigations support the general assumption that macroscopic properties like toxicity and ecotoxicity strongly depend on microscopic features and...

Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.

A general concept in risk assessment is that a threshold of exposure exists above which adverse effects are initiated. Toxicity related to the target-site concentration or biologically active dose. Although it often huge challenge measure specific dose metric metal toxicity, significant progress has been obtained approach closer concentration. Such developments reviewed present study. In additi...