BACKGROUND Ciprofloxacin generic tablets approved for human use frequently are administered to dogs for treatment of bacterial infections because they are inexpensive and readily available. However, previous work indicated low and variable oral absorption in healthy research dogs. OBJECTIVE To examine orally administered ciprofloxacin in a group of clinical canine patients using population ph...

The bioequivalence of three chemically equivalent paracetamol generic Mexican products (500 mg tablets) was evaluated in 12 healthy volunteers using the American innovator product (Tylenol, McNeil, Fort Washington, PA), as the reference. Single oral doses of each product were administered at 1-week intervals using a 4 x 4 Latin square design balanced for the first residual effect. The total amo...

Dissolution testing is a core performance test in pharmaceutical development and quality control. Generally, the HPLC method uses the analysis of dissolution testing. In this study, we attempted to improve the dissolution test by using microdialysis methods. We also investigated the comparison of the conventional HPLC dissolution method (batch-sampling method) and the improved dissolution test ...

Objective: To estimate plasma concentrations-time profiles of metronidazole commercial tablets through in vitro dissolution data using the Inverse Release Function approach and a convolution method. Methods: Dissolution reference (500 mg) were obtained USP Apparatus 1 at 100 rpm, 4 16 ml/min, 0.1 N HCl, pH 4.5 acetate buffer 6.8 phosphate as media. Additionally, three generic drug products test...

Introduction: hydrochlorothiazide is a diuretic drug indicated for the continuoustreatment of hypertension. The presented as medicine in form tabletscontaining only one active agent or combined formulations with concentrationsof 12.5, 25 and 50 mg. mg dosage most widely used medical therapy.Therefore, considering incidence hypertension prolonged use drug, it isnecessary to determine quality tab...