background: considering a few studies on the genetic basis of the cystinuria in the middle east and the population-specific distribution of mutations in the slc3a1 , we tried to find genetic variants in three exons (1, 3, and 8) of slc3a1 . materials and methods: in this study, exons 1, 3, and 8 of slc3a1 gene of 25 unrelated cystinuria patients searched for genetic variations by polymerase cha...

Multiple sclerosis (MS) is a chronic neurological disease affecting approximately 12 000 individuals in Sweden. Epidemiological studies have shown that most likely several genetic variations contribute and interact with each other as well as with environmental factors in the development of MS. The disease is characterized by focal infiltration of inflammatory cells in the brain and spinal cord,...

meriones crassus, meriones persicus, and meriones libycus from different areas of khorasan provinces and yazd province were studied by use of random amplified dna polymorphism (rapd) technique. dna samples were analyzed by use of nine primers. genetic distance among samples varied between 0.24 and 0.78. dendrogram designed on the base of genetic distance shows separation of these species. in th...

Body weight (BW) records (n=11,659) of 4961 Kurdi sheep from 215 sires and 2085 dams were used to estimate the additive genetic, direct and maternal permanent environmental effects on growth from 1 to 300 days of age. The data were collected from 1993 to 2015 at a breeding station in North Khorasan province; Iran. Genetic parameters for growth traits were estimated using random regression test-...

Five Indian geographical populations of Drosophila melanogaster were analyzed for their genetic divergence of life history traits. Clinal variations were observed for body weight, ovariole number, and four pre-life history traits (i.e., fecundity, hatchability, viability, and duration of development). Rearing populations at different growth temperatures shows that the variations among wild flie...

BACKGROUND Immune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses. METHODS Antibody responses to tetanus toxoid (TT), measles vaccines, and environ...

 ABSTRACT Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the ...