Pseudohypoparathyroidism, type I (PHP-I) is an inherited disorder of primary resistance to multiple hormones that work by stimulating adenylate cyclase. In an attempt to clarify the mode of inheritance of PHP-I, we measured the activity of the N protein, a receptor-cyclase coupling component, in erythrocyte membranes. Erythrocyte N-protein activity was reduced by approximately 50% in erythrocyt...

Understanding the biological principles of disease heredity and resistance to disease is a prerequisite for the incorporation of these factors into multi-trait breeding programmes. Mutations represent an evolutionary aspect of disease. The author reviews patterns of Mendelian inheritance and possible causes of non-Mendelian inheritance, such as multifactorial inheritance, expansion of trinucleo...

Parental education is the strongest measured predictor of offspring education, and thus many scholars see the parent-child correlation in educational attainment as an important measure of social mobility. But if social changes or policy interventions are going to have dynastic effects, we need to know what accounts for this intergenerational association, that is, whether it is primarily environ...

The scalp-ear-nipple (SEN) syndrome is an infrequent congenital disease. Its main features are scalp defects, malformed ears, and absence of nipples. Most of the reported cases are autosomal dominant. We report on a patient suffering SEN syndrome with possible autosomal recessive inheritance. It is concluded that SEN syndrome should be recognized as an entity with genetic heterogeneity once the...

The perpetuation of a family’s position in the distribution of income from parents to children reflects the genetic and cultural transmission of individual traits, as well as the inheritance of group memberships and income-earning assets. We show that the extent of intergenerational economic status transmission is considerably greater than was thought to be the case a generation ago, the geneti...

This chapter provides a tutorial introduction to the use of MCMC in the analysis of data observed for multiple genetic loci on members of extended pedigrees in which there are many missing data. We introduce the specification of pedigrees and inheritance, and the structure of genetic models defining the dependence structure of data. We review exact computational algorithms which can provide a p...

BACKGROUND/AIMS With pedigree data, genetic linkage can be detected using inheritance vector tests, which explore the discrepancy between the posterior distribution of the inheritance vectors given observed trait values and the prior distribution of the inheritance vectors. In this paper, we propose conditional inheritance vector tests for linkage localization. These conditional tests can also ...

production of high yielding hybrid cultivars is among the main objectives of breeding programs in sunflower and on evaluation of the combining ability of the inbred lines necessary to select for the appropriate parental lines for production of hybrid cultivars. this study was conducted to investigate the general and specific combining ability and the mode of inheritance for agronomic and seed q...

Copy number variations (CNVs) are being used as genetic markers or functional candidates in gene-mapping studies. However, unlike single nucleotide polymorphism or microsatellite genotyping techniques, most CNV detection methods are limited to detecting total copy numbers, rather than copy number in each of the two homologous chromosomes. To address this issue, we developed a statistical framew...

Genetic Programming GP is an automatic method for generating computer programs which are stored as data structures and manipulated to evolve better programs An extension restricting the search space is Strongly Typed Genetic Programming STGP which has as a basic premise the removal of closure by typing both the arguments and return values of functions and by also typing the terminal set A restr...