Synthetic inorganic-organic composites are of interest for bone tissue engineering as an alternative to natural grafts, since they resemble the structure and degrade over time, enabling new grow. In this study, properties two types composite materials: Type 1) genipin cross-linked chitosan hydrogels with addition Bioglass 45S5 (BG) powder 2) BG scaffolds coated hydrogel, have been investigated ...

Geniposide is a key iridoid glycoside from Gardenia jasminoides fructus widely used in traditional Chinese herbal medicine. However, detection of this small molecule represents a significant challenge mostly due to the lack of specific molecular recognition elements. In this study, we have performed in vitro selection experiments to isolate DNA aptamers that can specifically bind geniposide. Us...

summary The objective of this study was to enhance the mechanical and thermo-mechanical properties of electrospun gelatin nanofibers, while maintaining their good bioactivity. In this work, genipin was used as crosslinker to achieve this goal. Electrospun gelatin nanofibers were crosslinked with genipin vapor at room temperature for 0 h, 6 h, 12 h, 24 h, 48 h and 72 h. The morphologies of the c...

Chitosan (CS), the deacetylated form of chitin, the second most abundant, natural polysaccharide, is attractive for applications in the biomedical field because of its biocompatibility and resorption rates, which are higher than chitin. Crosslinking improves chemical and mechanical stability of CS. Here, we report the successful utilization of a new set of crosslinkers for electrospun CS. Genip...

The synthesis of genipin cross-linked gelatin (Gelapin) hydrogel materials is presented. Gelapin hydrogels were comprehensively characterised through chemical, mechanical and physical analysis techniques. It was found that the hydrogels could be cross-linked to up to 90% using a genipin concentration of 24.4% (w/ w). The hydrogels reach a stable swollen state and cease leaching of residual star...

We have previously demonstrated that a natural iridoid compound, genipin, induces neurite outgrowth mediated by nitric oxide (NO) production in PC12h cells. However, genipin could not induce neurite outgrowth by PC12 cells, the parental cells of PC12h cells. The difference in neuritogenic response to genipin may be due to a lack of neuronal NO synthase (NOS) protein, most likely neuronal NOS, i...

The purpose of this work was to investigate the anti-depressant effect of genipin and its mechanisms using (1)H-NMR spectroscopy and multivariate data analysis on a chronic unpredictable mild stress (CUMS) rat model. Rat serum and urine were analyzed by nuclear magnetic resonance (NMR)-based metabonomics after oral administration of either genipin or saline for 2 weeks. Significant differences ...

Antimicrobial delivery has been advocated for guided tissue regeneration (GTR) or guided bone regeneration (GBR) therapies involving patients with aggressive or unresolved periodontitis/peri-implantitis. Electrospun chitosan membranes demonstrate several advantages over traditional GTR barrier membranes because they stimulate healing, mimic the topology of the extracellular matrix, and allow fo...

This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to monitor the dynamic viscoelastic parameters during in situ (i.e., in the rheom...

A variety of light sources and reagents are available for the detection and identif ication of latent prints. This study was undertaken to explore the optimum light and f ilter combinations of laser and light-emitting diode (LED) light for use with indanedione and two new reagents, genipin and lawsone. The light sources utilized were Coherent TracER lasers operating at 460 nm, 532 nm, and 577 n...