objective: this study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of gdm. materials and methods: total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy,admitted to  mirza koochakkhan hospital, tehran in january 2008 - january 2009 entered to this randomized controlled clinical trial. the wo...

IN BRIEF Insulin remains the standard of care for the treatment of type 1 diabetes, type 2 diabetes, and uncontrolled gestational diabetes. Tight control maintained in the first trimester and throughout pregnancy plays a vital role in decreasing poor fetal outcomes, including structural anomalies, macrosomia, hypoglycemia of the newborn, adolescent and adult obesity, and diabetes. Understanding...

315 Introduction In recent times, there have been two striking developments in the area of insulin therapy. On the therapy front, insulin therapy especially in type 2 diabetes has become a topic frequently reviewed in literature (Marre, 2000; Korytkowski, 2000). These reviews discuss the role of early insulin initiation in the light of the growing burden of type 2 diabetes coupled with the need...

Gestational diabetes mellitus (GDM) is a new epidemic among Australian women, especially those with Asian backgrounds. The 1998 Australia National Diabetes Strategy and Implementation Plan recognises GDM as an independent glucose metabolic disorder affecting sub-groups of Australians. Gestational diabetes mellitus is an Australian national diabetes priority area, along with insulin dependent di...

Methods We examine the prevalence of MetS in a cohort of Caucasian women with previous gestational diabetes (GDM) (n=116), and those with normal glucose tolerance (NGT) during pregnancy (n=51). Fasting glucose alone (known DM/pre-diabetes post-partum patients) or 75g OGTT (other patients), lipid profile, insulin and c-peptide were performed. We calculated insulin resistance using the HOMA2-IR c...

OBJECTIVE To identify physiological and clinical variables associated with development of type 2 diabetes up to 12 years after pregnancies complicated by gestational diabetes. RESEARCH DESIGN AND METHODS Seventy-two islet cell antibody-negative nondiabetic Hispanic women had oral (oGTT) and intravenous (ivGTT) glucose tolerance tests, glucose clamps, and body composition assessed between 15 a...

C-peptide, a key biomarker for beta-cell function in diabetes, has potential understanding and managing the disease, though its application type 2 diabetes is limited by insufficient evidence. It provides insights into endogenous insulin secretion faces challenges measurement standardization. In 1 C-peptide levels reflect beta cell loss, while higher indicate risk of progression. Preserved diff...

BACKGROUND Although breastfeeding is expected to reduce the incidence of diabetes in women with gestational diabetes, the effect has not been clearly confirmed. We examined whether or not high-intensity breastfeeding reduces the incidence of abnormal glucose tolerance and investigated the effect of high-intensity breastfeeding on insulin resistance during the first year postpartum in Japanese w...

BACKGROUND Pregnant women with mild gestational hyperglycemia present high risk for hypertension, obesity and hyperglycemia, and appeared to reproduce the model of metabolic syndrome in pregnancy, with hyperinsulinemia and insulin resistance. Our clinical studies showed that mild gestational hyperglycemia or gestational diabetes are related to similar adverse maternal and perinatal outcomes. Hy...

BACKGROUND Term infants who are small for gestational age appear prone to the development of insulin resistance during childhood. We hypothesized that insulin resistance, a marker of type 2 diabetes mellitus, would be prevalent among children who had been born prematurely, irrespective of whether they were appropriate for gestational age or small for gestational age. METHODS Seventy-two healt...