نتایج جستجو برای: giant cell osteosarcoma
تعداد نتایج: 1734734 فیلتر نتایج به سال:
Abstract: Background and Aim: Giant cell Granulomas (central and peripheral) are two fairly common lesions of the oral cavity with uncertain etiology and pathogenesis. As well, the reason for their different biologic behavior is not well understood yet. This study aimed to review the immunohistochemical profile of giant cell granuloma and its correlation with pathogenesis and biologic behavior....
Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and radiation oncologists, and surgeons and radiologists with demonstrated expertise in the management of these tumors. Long-term surveillance and follow-u...
Denosumab, a human monoclonal antibody that inhibits bone resorption by binding on the receptor activator of the nuclear factor kappa-β ligand, has recently emerged as an additional option in the treatment of musculoskeletal osteolytic tumors. This article focuses on the recent literature regarding the effectiveness of denosumab in the management of giant cell tumor, multiple myeloma, aneurysma...
Fine needle aspiration (FNA) cytology was performed on 62 primary and 22 metastatic bone tumours. Histological correlation was available in all 62 primary bone tumours, which included 7 benign and 53 malignant tumours. The most common of the malignant tumours were Ewing's sarcoma, followed by giant cell tumour, osteosarcoma and chondrosarcoma. The benign tumours included 4 enchondromas, 1 chond...
Cherubism is a rare disorder with autosomal dominant inheritance. It is classified as a benign fibro-osseous lesions and may involve either facial bone. Its typical dentofacial deformities are caused by mutations in the SH3BP2 gene. The protein encoded by SH3BP2 had a significant role in the regulation of osteoblasts and osteoclasts. Accordingly with the radiological findings, differential diag...
: Tumor relapse and pulmonary metastasis, especially unresectable lesions, are the major cause of poor prognosis patients with osteosarcoma. Anlotinib, a novel small-molecule tyrosine kinase inhibitor (TKI), has been proved to have desirable anti-tumor effects via blocking VEGFR2 PDGFRβ phosphorylation in several tumors, including non-small cell lung cancer soft tissue sarcoma. In this study, w...
Two rare cases of extra-articular diffuse variant giant cell tumor of the tendon sheath are presented, at the elbow of a 68-year-old female and the foot of a 56-year-old male. Both patients presented with a palpable masses and marginal excision was performed; histological sections confirmed the diagnosis of extra-articular giant cell tumor. No adjuvant therapy was administered. At the last fo...
molecular mechanisms of luteolin induced growth inhibition and apoptosis of human osteosarcoma cells
luteolin is a flavone in medicinal plants as well as some vegetables and spices. it is a natural anti-oxidant with less pro-oxidant potential but apparently with a better safety profile. the purpose of this study was to investigate the molecular mechanism of luteolin-mediated apoptosis of mg-63 human osteosarcoma cells. mtt assay kit was employed to evaluate the effects of luteolin on mg-63 cel...
Background Osteosarcoma (OS) is a prevalent bone cancer characterized by its aggressive nature, which often metastasizes to the lungs and contributes poor prognosis. Treatment progress has been hindered drug resistance, distant metastases, significant patient heterogeneity. However, recent advancements in technologies such as sequencing multi-omics have enabled more in-depth investigations at m...
Central hemangioma, a bone destructive lesion, is a benign tumor. Hemangiomas of jaws are rare entity and produces many different radiographic images. Radiographic differential diagnosis includes osteosarcoma, fibrous dysplasia, central giant cell granuloma, ameloblastoma, odontogenic myxoma, multiple myeloma, dentigerous cyst and aneurysmal bone cyst. Since it involves proliferation of blood v...
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