BACKGROUND In daily clinical practice of a dental department it's common to find gingival overgrowth (GO) in periodontal patients under treatment with Cyclosporine A (CsA). The pathogenesis of GO and the mechanism of action of Azithromycin (AZM) are unclear. A systematic review was conducted in order to evaluate the efficacy of Azithromycin in patients with gingival overgrowth induced by assump...

OBJECTIVES Gingival overgrowth is a complication of cyclosporine therapy following organ transplantation. Oral azithromycin is frequently used to treat this complication. This study examined the efficacy of local azithromycin, in the form of toothpaste, against cyclosporine-induced gingival overgrowth. MATERIALS AND METHODS Twenty stable renal transplanted patients (10 men and 10 women) with ...

abstract background: although cyclosporine (csa) and calcium channel blockers (ccbs) parallel to each other may provoke gingival enlargement (ge), there are few considerations about combined effects of csa and ccbs on gingival tissues. objectives: this study aimed to determine prevalence of ge among renal transplant recipients and to compare its occurrence in patients who received only csa and ...

Cyclosporine A, a drug that inhibits the immune response, has been widely used for over 30 years in immu‐ nosuppressive therapy protocols for patient‐recipients of the transplanted organs. One of the commonly reported side effects of Cyclosporine A is gingival overgrowth, with varying degrees of severity, which may interfere with the aesthetics and normal functions of the oral cavity. Combi‐ na...

Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). The HGF were treated with CSA and TNF-alpha or PDGF. DNA-binding activity of NF...

BACKGROUND Gingival hyperplasia is a known complication of cyclosporin therapy. Although plaque control has been shown to be of benefit, gingival surgery is occasionally necessary. The aim of this study was to review the effect of a short-course therapy with azithromycin in renal transplant patients with cyclosporin-induced gingival hyperplasia. METHODS Thirty-eight patients received 500 mg/d...

Non-plaque induced diffuse gingival overgrowth represents a broad class of conditions caused by several etiological factors. The aim this review is to highlight the most recent updates and classifications all existent overgrowths. In addition, we highlighted diagnostic pathway that should be employed in patients affected overgrowth. Gingival can related syndromic diseases including wide spectru...

The effect of tenidap [(+/-)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide], a new anti-inflammatory agent, was investigated on DNA synthesis by means of [(3)H]thymidine incorporation, collagen synthesis by means of [(3)H]proline incorporation, cell proliferation, and intracellular pH in nicardipine-reactive human gingival fibroblasts. Tenidap significantly i...

Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly progressive, local or diffuse enlargements within marginal and attached gingiva or interdental papilla. In severe cases, the excess tissue may cover the crowns of the teeth, thus causing functional, esthetic, and periodontal problems, such as bone loss and bleeding, due to the presence of pseudopockets a...