Comet 1P/Halley has the unique distinction of having a very comprehensive set of observational records for almost every perihelion passage from 240 B.C. This has helped to constrain theoretical models pertaining to its orbital evolution. Many previous works have shown the active role of mean motion resonances in the evolution of various meteoroid streams. Here we look at how various resonances,...

Project Title: A Distributed Information Management Framework (REGNET) for Environmental Laws and Regulations Grant No.: EIA-0085998 Principal Investigators: Kincho H. Law, Gio Wiederhold, Jim Leckie and Barton Thompson Research Assistants: Shawn Kerrigan, Gloria T. Lau, Bill Labiosa, Charles Heenan, Haoyi Wang, Liang Zhou, Pooja Trivedi, Jun Peng Institution: Stanford University Websites: http...

Solving a quadratic equation P (x) = ax + bx+ c = 0 with real coefficients is known to middle school students. Solving the equation over the quaternions is not straightforward. Huang and So [2] give a complete set of formulas, breaking it into several cases depending on the coefficients. From a result of the second author in [10], zeros of P (x) can be expressed in terms of the zeros of a real ...

OBJECTIVE Long-term glucocorticoid use is accompanied by rapid bone loss; however, early treatment with bisphosphonates prevents bone loss and reduces fracture risk. The aim of this study was to examine the effects of two bisphosphonates, i.v. zoledronic acid (ZOL) versus oral risedronate (RIS), on bone turnover markers (BTMs) in subjects with glucocorticoid-induced osteoporosis (GIO). METHOD...

Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases. However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteoporosis (GIO). Over the last years, several clinical practice guidelines emphasize the need of prev...

With the recent advent of RNA-seq technology the proteomics community has begun to generate sample-specific protein databases for peptide and protein identification, an approach we call proteomics informed by transcriptomics (PIT). This approach has gained a lot of interest, particularly among researchers who work with nonmodel organisms or with particularly dynamic proteomes such as those obse...

Glucocorticoid-induced osteoporosis (GIO) is one of the major side effects of long-term glucocorticoid (GC) therapy mediated mainly via the suppression of bone formation and osteoblast differentiation independently of GC receptor (GR) dimerization. Since microRNAs play a critical role in osteoblast differentiation processes, we investigated the role of Dicer dependent microRNAs in the GC-induce...