The Tec family kinase Btk plays an important role in the regulation of phospholipase C gamma 2 (PLC gamma 2) downstream of the collagen receptor glycoprotein VI (GPVI) in human platelets. Platelets also express a second member of this family, Tec; however, its function has not been analyzed. To address the role of Tec, we analyzed Btk-/-, Tec-/-, and Btk/Tec double-deficient (Btk-/-/Tec-/-) pla...

The Tec family kinase Btk plays an important role in the regulation of phospholipase C 2 (PLC 2) downstream of the collagen receptor glycoprotein VI (GPVI) in human platelets. Platelets also express a second member of this family, Tec; however, its function has not been analyzed. To address the role of Tec, we analyzed Btk / , Tec / , and Btk/Tec double-deficient (Btk / /Tec / ) platelets. Tec ...

Monitoring earthquakes to rapidly forecast their consequences remains a challenging task, especially in areas far from seismic and geodetic networks. Large shallow induce disturbances the ionospheric Total Electron Content (TEC). These are commonly detected using Global Navigation Satellite Systems (GNSS) stations that can sound ionosphere at great distances. To address this instrumentation spa...

This paper represents linkage network of queues consisting of biserial and parallel servers linked to a common server in series with a flowshop scheduling system consisting of two machines. The significant transportation time of the jobs from one machine to another is also considered. Further, the completion time of jobs/customers (waiting time + service time) in the queue network is the set...

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain +/-5 ng immunoreactive (ir) NT/10(6) cells, of which 5% is associated with plasma cell membranes. HPLC analysis of NT-ir present in human TEC showed a major peak of NT-ir corresponding to NT1-1...

A low mass time expansion chamber (TEC) has been developed to measure distributions of position and angle of the TRIUMF low energy surface muon beam used for the TWIST experiment. The experiment is a high precision measurement of muon decay and is dominated by systematic uncertainties, including the stability, reproducibility, and characterization of the beam. The distributions measured by two ...

Among cytoplasmic protein-tyrosine kinases (PTKs) Tec now forms a novel subfamily with recently identified Tec-related PTKs (Btk and ltk/Tsk). Tec is known to be abundantly expressed in myeloid cells, and multiple forms of Tec protein can be generated via the mechanism of alternative splicing. In this report, we have inveatigated 5“terminal diversity of the tec messages to demonstrate a predomi...

Tumor blood vessels play an important role in tumor progression and metastasis. We previously reported that tumor endothelial cells (TEC) exhibit several altered phenotypes compared with normal endothelial cells (NEC). For example, TEC have chromosomal abnormalities and are resistant to several anticancer drugs. Furthermore, TEC contain stem cell-like populations with high aldehyde dehydrogenas...

The ionospheric total electron content (TEC) is a significant parameter for scientific studies of the ionosphere and space weather. Ground-based Global Navigation Satellite System (GNSS) station network provides an opportunity modeling TEC with high accuracy. Based on global maps, by using data from International GNSS Service (IGS) stations 21 years (from 1998 to 2018), we establish climate ind...