Human thermoregulation and acclimatization are core components of the human coping mechanism for withstanding variations in environmental heat exposure. Amidst growing recognition that curtailing global warming to less than two degrees is becoming increasing improbable, human survival will require increasing reliance on these mechanisms. The projected several fold increase in extreme heat event...

The self-adaptation of the mutation distribution is a distinguishing feature of evolutionary algorithms that optimize over continuous variables. It is widely recognized that self-adaptation accelerates the search for optima and enhances the ability to locate optima accurately, but it is generally unclear whether these optima are global ones or not. Here, it is proven that the probability of con...

Equity and efficiency should be considered when allocating resources for climate change adaptation. More than a decade after the Least Developed Countries Fund approved adaptation funds for 18 countries in 2003, it is possible to take the stock of investment data and to test empirically whether equity and efficiency have been factored into adaptation investment decision-making. To evaluate equi...

We propose a new method called Stochastic Model Reference Adaptive Search (SMRAS) for finding a global optimal solution to a stochastic optimization problem in situations where the objective functions cannot be evaluated exactly, but can be estimated with some noise (or uncertainty), e.g., via simulation. SMRAS is a generalization of the recently proposed Model Reference Adaptive Search (MRAS) ...

Adaptation in signaling systems, during which the output returns to a fixed baseline after a change in the input, often involves negative feedback loops and plays a crucial role in eukaryotic chemotaxis. We determined the dynamical response to a uniform change in chemoattractant concentration of a eukaryotic chemotaxis pathway immediately downstream from G protein-coupled receptors. The respons...